Products Cinnamon is commercially available, among other things, as a spice, as a medicinal drug, tea and in the form of capsules as a dietary supplement. It is found in remedies for digestion such as Carmol, Klosterfrau Melissengeist and in Zeller Balsam. Cinnamon is also a component of traditional pharmaceutical preparations such as aromatic tincture … Cinnamon
Products Entacapone was commercially available in the form of film-coated tablets (Comtan). It was approved in many countries since 1999. In 2017, distribution was discontinued. A fixed combination with levodopa and carbidopa has also been available since 2004 (Stalevo). Generic versions of the combination drug were approved in 2014. Structure and properties Entacapone (C14H15N3O5, Mr … Entacapon
Products Tolcapone is commercially available in the form of film-coated tablets (Tasmar). It has been approved in many countries since 1997. Structure and properties Tolcapone (C14H11NO5, Mr = 273.2 g/mol) exists as a yellow, odorless, non-hygroscopic, crystalline powder. It is a nitrobenzophenone. Effects Tolcapone (ATC N04BX01) affects the pharmacokinetics of levodopa. The effects are due … Tolcapon
Products In many countries, there are no finished medicines containing amineptine on the market. Amineptin is one of the narcotics and requires an aggravated prescription. It was withdrawn from the market in France and other European countries in 1999 (Survector, Servier). Structure and properties Amineptine (C22H27NO2, Mr = 337.5 g/mol) belongs to the tricyclic antidepressants. … Amineptin
Products Temozolomide is commercially available as capsules and as a powder for the preparation of an infusion solution (Temodal, generics). It has been approved in many countries since 1999. Structure and properties Temozolomide (C6H6N6O2, Mr = 194.2 g/mol) is an imidazotetrazine derivative. It is a prodrug that is biotransformed by hydrolysis to the active metabolite … Temozolomide
Products Regorafenib is commercially available in the form of film-coated tablets (Stivarga). It was approved in many countries in February 2013. Structure and properties Regorafenib (C21H15ClF4N4O3, Mr = 482.8 g/mol) is present in drugs as regorafenib monohydrate, which is practically insoluble in water. Effects Regorafenib (ATC L01XE21) has antitumor and antiangiogenic properties. The effects are … Regorafenib
Products Ximelagatran (Exanta, film-coated tablets) was withdrawn from the market or not approved in some countries in 2006 because liver-toxic properties had been observed in clinical trials. Structure and properties Ximelagatran (C24H35N5O5, Mr = 473.6 g/mol) is a prodrug that is biotransformed in the organism to the active metabolite melagatran. Melagatran was itself also commercially … Ximelagatran
Products Tipranavir is commercially available in capsule form (Aptivus). It has been approved in many countries since 2005. Structure and properties Tipranavir (C31H33F3N2O5S, Mr = 602.7 g/mol) exists as a white to slightly yellowish substance that is insoluble in an aqueous buffer at pH 7.5. Tipranavir has a nonpeptidic structure. Effects Tipranavir (ATC J05AE09) has … Tipranavir
Products Daclizumab was approved in the United States and EU in 2016 and in many countries in 2017 as a solution for injection for MS treatment (Zinbryta). In 2018, the drug was withdrawn from the market due to serious adverse effects. These adverse effects included liver damage and reports of encephalopathies (encephalitis, meningoencephalitis). Daclizumab had … Daclizumab
Products Teriflunomide is commercially available in the form of film-coated tablets (Aubagio). It was approved in many countries in 2013. Teriflunomide can be taken perorally, unlike earlier MS medications, and does not need to be injected. Structure and properties Teriflunomide (C12H9F3N2O2, Mr = 270.2 g/mol) is the active metabolite of the prodrug leflunomide (Arava), which … Teriflunomide
Products Leflunomide is commercially available in the form of film-coated tablets (Arava, generics). It has been approved in many countries since 1998. In 2011, generic versions went on sale in many countries. Structure and properties Leflunomide (C12H9F3N2O2, Mr = 270.2 g/mol) is an isoxazole carboxamide. It is a prodrug and is biotransformed in the intestine … Leflunomide
Products Most HIV protease inhibitors are commercially available in tablet or capsule form. In addition, a few liquid dosage forms are available for ingestion. Saquinavir (Invirase) was the first to be lanicized in 1995. Structure and properties The first HIV protease inhibitors were modeled on the natural peptide substrate of the HIV protease. The protease … HIV Protease Inhibitor