Products Lepirudin was commercially available as a lyophilizate (Refludan). It was approved in many countries in 1997 and is no longer on the market. Structure and properties Lepirudin is a derivative of hirudin from the leech. Effects Lepirudin (ATC B01AX03) is anticoagulant by direct inhibition of thrombin. Indications Heparin-associated thrombocytopenia (HAT) type II.
Products Ximelagatran (Exanta, film-coated tablets) was withdrawn from the market or not approved in some countries in 2006 because liver-toxic properties had been observed in clinical trials. Structure and properties Ximelagatran (C24H35N5O5, Mr = 473.6 g/mol) is a prodrug that is biotransformed in the organism to the active metabolite melagatran. Melagatran was itself also commercially … Ximelagatran
Products Bivalirudin was commercially available as a powder for preparation of a concentrate for solution for injection or infusion (Angiox). It was approved in many countries as of 2007. It has since become unavailable. Structure and properties Bivalirudin originated from hirudin, an anticoagulant substance found in leeches. Effects Bivalirudin (ATC B01AE06) has antithrombotic properties. Indications … Bivalirudin
