VEGF Inhibitors

Products VEGF inhibitors are commercially available as injectables from various suppliers. The first agent in this group to be approved was pegaptanib (Macugen) in 2004, which is now off the market in many countries. Structure and properties The currently available VEGF inhibitors are therapeutic proteins (biologics). They are antibodies, antibody fragments, and fusion proteins. They … VEGF Inhibitors

Teriparatide

Products Teriparatide is commercially available as a solution for injection in a prefilled injector (Forsteo, some countries also: Forteo). It was approved in the United States in 2002 and in the EU and many countries in 2003. The drug must be stored in a refrigerator and must not be frozen. Biosimilars are approved in many … Teriparatide

Testosterone Effects

Products Testosterone is commercially available as a drug product including transdermal gel, transdermal patch, transdermal solution, and injectable. In some countries, other dosage forms such as buccal tablets are available. Andriol Testocaps capsules have been discontinued in many countries since 2020. Structure and properties Testosterone (C19H28O2, Mr = 288.4 g/mol) is a steroid. It exists … Testosterone Effects

Dexamethasone: Drug Effects, Side Effects, Dosage and Uses

Products Dexamethasone is found in numerous medications. This article refers to peroral administration in the form of tablets (fortecortin, generic). See also the article Cortisone Tablets. Structure and properties Dexamethasone (C22H29FO5, Mr = 392.5 g/mol) exists as a white, crystalline, and odorless powder that is practically insoluble in water. It is a fluorinated and methylated … Dexamethasone: Drug Effects, Side Effects, Dosage and Uses

Air Travel Thrombosis

Symptoms Deep vein thrombosis develops as a result of a blood clot in the deep veins. Typical symptoms are: Painful and swollen legs and calves, edema. Redness and discoloration of the skin Locally increased temperature Often asymptomatic It poses a significant risk for the development of pulmonary embolism when part of the thrombus breaks loose … Air Travel Thrombosis

Gabapentin: Drug Effects, Side Effects, Dosage and Uses

Products Gabapentin is commercially available in the form of capsules and film-coated tablets (Neurontin, generic). It has been approved in many countries since 1994. Pfizer launched pregabalin (Lyrica) as its successor in 2004. Structure and properties Gabapentin (C 9 H 17 NO 2 , M r = 171.2 g/mol) is structurally a GABA analog and … Gabapentin: Drug Effects, Side Effects, Dosage and Uses