Definition In drug therapy, “off-label use” refers to deviations from the officially approved specifications in the drug information leaflet of approved drugs that are ready for use. Frequently, this concerns the areas of application (indications). However, other changes also fall under the definition, for example with regard to the dose, duration of therapy, patient groups, … Off-Label Use
Products Cromoglicic acid had been approved for asthma therapy in many countries since 1969. After the original Lomudal, the generic Cromosol UD also went off the market in 2016. Medicines for inhalation are still available in Germany. Structure and properties The drugs contain sodium cromoglicate (C23H14Na2O11, Mr = 512.3 g/mol), a white, crystalline, hygroscopic powder … Cromoglicic Acid in Asthma
Symptoms Itching Lice and nits in the pubic hair Gray to blue skin patches (maculae ceruleae, “taches bleues”) at the injection sites Reddish brown spots on the underwear Causes The blood-sucking crab louse is a wingless insect about 1 to 2 mm long with 6 legs and large foot claws on the 2nd and 3rd … Pubic Lice (Crabs): Causes and Treatment
Products Carbamazepine is commercially available as tablets, sustained-release tablets, suspension, and syrup (Tegretol, generics). It has been approved in many countries since 1963. Structure and properties Carbamazepine (C15H12N2O, Mr = 236.3 g/mol) exists as a white crystalline powder that is very sparingly soluble in water. It has a tricyclic structure and an active metabolite, carbmazepine-10,11-epoxide. … Carbamazepine Effects and Side Effects
Symptoms Local skin reactions such as itching, inflammation, redness, and blistering occur acutely, especially at the sites of contact with the trigger. In the chronic stage, dry, scaly and cracked skin is often observed, e.g. in the form of chronic hand eczema. Affected areas include the hands, abdomen and earlobes. The rash can also appear … Metal Allergy
Symptoms Restless legs syndrome manifests as an uncomfortable and difficult-to-describe feeling in the legs and a strong urge to move the legs. Less commonly, the arms are also affected. The unilateral or bilateral insensations include, for example, a burning sensation, pain, pressing, creeping and a pulling sensation. The discomfort occurs mainly at rest, for example, … Restless Legs Syndrome Causes and Treatment
Products Androgens are commercially available as oral tablets and capsules, transdermal gels and transdermal patches, and injectables, among others. Testosterone was first isolated in the 1930s. Structure and properties Androgens generally have a steroidal structure and are related to testosterone. They are steroid hormones that are often present as esters in drugs. Effects Androgens (ATC … Androgens: Steroid Hormones
Products Trimipramine is commercially available in tablet and drop form (Surmontil, generic). It has been approved in many countries since 1962. Structure and properties Trimipramine (C20H26N2, Mr= 294.5 g/mol) is present in drugs as trimipramine mesilate or trimipramine maleate, a racemate and white crystalline powder that is sparingly soluble in water. It is structurally closely … Trimipramine
Products Halofantrine was approved in 1988 and is now no longer available as a finished drug in many countries and many more. Halfan tablets (GlaxoSmithKline AG, 250 mg) are off the market. Structure and properties Halofantrine (C26H30Cl2F3NO, Mr = 500.4 g/mol) is a racemate and a halogenated phenanthrene derivative. It is also known as phenanthrene … Halofantrine
Products Trazodone is commercially available in the form of film-coated tablets and sustained-release tablets (Trittico, Trittico retard, Trittico Uno). The active ingredient was developed at Angelini in Italy in 1966 and has been approved in many countries since 1985. Auto-generics and generics are registered. Generic versions of the 100 mg film-coated tablets first went on … Trazodone
Products Tiagabine was commercially available in the form of film-coated tablets (gabitril). It was approved in many countries in 1996 and went off the market in June 2012. Structure and properties Tiagabine (C20H25NO2S2, Mr = 375.5 g/mol) is a piperidine and thiophene derivative. It exists as a white crystalline powder that is sparingly soluble in … Tiagabine
Symptoms Frostbites are inflamed, superficial, painful, itchy to burning, swollen, reddened to blue-purple skin lesions (patches, papules, plaques). They occur recurrently on both sides, especially dorsally on the fingers and toes. Other exposed areas such as ears, face, nose and thighs may also be affected. Frostbite is most commonly seen in winter and spring. Possible … Frostbite Symptoms and Causes
