Products Sodium picosulfate is commercially available in the form of tablets, soft capsules (pearls), and drops (e.g., Laxoberon, Dulcolax Picosulfate). It has been approved in many countries since 1973. Structure and properties Sodium picosulfate (C18H13NNa2O8S2, Mr= 481.41 g/mol) is structurally closely related to bisacodyl. The difference is that it is esterified with sulfuric acid instead … Sodium Picosulfate
Products Naloxegol is commercially available in the form of film-coated tablets (Moventig, USA: Movantik). It was approved in many countries in 2015. Structure and properties Naloxegol (C34H53NO11, Mr = 651.8 g/mol) is a pegylated derivative of naloxone. It exists as naloxegoloxalate, a white powder that is highly soluble in water. Effects Naloxegol (ATC A06AH03) is … Naloxegol
Products Methylnaltrexone is commercially available as a solution for injection (Relistor). It has been approved in many countries since 2009. Structure and properties Methylnaltrexone (C21H26NO4, Mr = 356.4 g/mol) is an -methylated naltrexone. It is present in drugs as methylnaltrexone bromide. Effects Methylnaltrexone (ATC A06AH01) counteracts constipation caused by opioids. The effects are due to … Methylnaltrexone
Products Lubiprostone is commercially available in the form of soft capsules (Amitiza). It has been approved in many countries since 2009. Structure and properties Lubiprostone (C20H32F2O5, Mr = 390.46) is a white, odorless powder that is insoluble in water and soluble in ethanol and ether. It is a derivative of a metabolite of prostaglandin E1. … Lubiproston
Products and production Morphine drops are an aqueous dropping solution of morphine hydrochloride, usually in concentration 1% or 2%, maximum 4%. The concentration refers to the salt; the effective amount of morphine base is less. The drug is subject to strict control as an anesthetic and is available only on prescription. The morphine drops of … Morphine Drops
Symptoms Drug therapy with opioids for pain, cough, or diarrhea often results in constipation as an adverse effect. Triggers include, for example, morphine, codeine, oxycodone, tramadol, fentanyl, or buprenorphine. Constipation limits quality of life and can lead to accompanying symptoms and complications such as nausea, vomiting, bloating, abdominal cramps, hemorrhoids, and bowel obstruction. Laxative abuse … Opioids and Constipation
Products The fixed combination Targin with the active ingredients oxycodone and naloxone was approved in many countries in 2009. In other countries, the drug is also known as Targinact or Targiniq. In 2016, generic versions were approved in many countries. They went on sale in 2018. Structure and properties Oxycodone (C18H21NO4, Mr = 315.4 g/mol) … Oxycodone, Naloxone
