Symptoms Low blood pressure does not necessarily cause symptoms and often remains asymptomatic. Possible symptoms include: Pale and cold skin, cold hands and feet, sweating. Visual disturbances: Blackening in front of the eyes, flickering, parts of the visual field fail Concentration disorders Rapid pulse, palpitations Ringing in the ears Dizziness Weakness, fatigue, lack of performance … Low Blood Pressure
Products Doxazosin is commercially available in the form of sustained-release film-coated tablets (Cardura CR, generic). It has been approved in many countries since 1999. Structure and properties Doxazosin (C23H25N5O5, Mr = 451.5 g/mol) is present in drugs as doxazosin mesilate, a quinazoline derivative and a white crystalline powder that is sparingly soluble in water. Effects … Doxazosin
Products Molsidomine is commercially available in the form of tablets and sustained-release tablets (Corvaton). The drug has been approved in many countries since 1980. Structure and properties Molsidomine (C9H14N4O4, Mr = 242.2 g/mol) is a prodrug that is biotransformed in the liver to the active metabolite linsidomine (SIN-1). It exists as a white crystalline powder … Molsidomin
Products Riociguat is commercially available in the form of film-coated tablets (Adempas). It was approved in many countries in 2013. Riociguat is the first active ingredient from this group of drugs. Structure and properties Riociguat (C20H19FN8O2, Mr = 422.4 g/mol) exists as a white to yellow, crystalline, non-hygroscopic substance that is sparingly soluble in water. … Riociguat
Symptoms Pulmonary arterial hypertension may initially be asymptomatic. It manifests as symptoms such as difficulty breathing that worsens with exertion, shortness of breath, fatigue, chest pain, brief loss of consciousness, cyanosis, and palpable heartbeats. Possible complications include cor pulmonale, blood clots, arrhythmias, and bleeding. Causes The condition is caused by an increase in pressure in … Pulmonary Arterial Hypertension
Symptoms Urinary incontinence manifests as involuntary leakage of urine. The common problem poses a psychosocial challenge for those affected, which can lead to changes in personal activities and a loss of quality of life. Risk factors include female gender, age, obesity, and numerous medical conditions. Causes Urinary incontinence can occur as a result of pathologic, … Urinary Incontinence: Causes and Treatment
Products Phosphodiesterase-5 inhibitors are commercially available in the form of film-coated tablets and meltable tablets. Sildenafil (Viagra) was the first active ingredient from this group to be approved in the United States, the EU, and many countries in 1998. Generics are also available today. Sildenafil was originally to be developed by Pfizer for the treatment … Phosphodiesterase-5 Inhibitors
Products Alpha blockers are available in many countries in the form of tablets, sustained-release tablets, capsules, and sustained-release capsules. The most commonly prescribed today is tamsulosin (Pradif T, generic). Alpha blocker is short for alpha1-adrenoreceptor antagonist. Structure and properties The first alpha blockers-alfuzosin, doxazosin, and terazosin-were developed as derivatives of quinazoline: Effects Alpha blockers (ATC … Alpha Blocker
Products Avanafil is commercially available in tablet form (Spedra, some countries: Stendra). It was approved in the US in April 2012, in the EU in 2013, and in many countries in 2016. Structure and properties Avanafil (C23H26ClN7O3, Mr = 483.95 g/mol) is a pyrimidine derivative. It exists as a white crystalline powder that is practically … Avanafil
