Products Axitinib was approved in many countries in 2012 in film-coated tablet form (Inlyta). Structure and properties Axitinib (C22H18N4OS, Mr = 386.5 g/mol) is a benzamide and benzindazole derivative. It exists as a white to slightly yellow powder. Effects Axitinib (ATC L01XE17) has antitumor properties. The effects are due to inhibition of VEGFR-1, -2, and … Axitinib
Products Apalutamide was approved in the US and EU in 2018 and in many countries in 2019 in film-coated tablet form (Erleada). Structure and properties Apalutamide (C21H15F4N5O2S, Mr = 477.4 g/mol) exists as a white to slightly yellow powder that is practically insoluble in water. The active metabolite -demethylapalutamide is also active, but more weakly … Apalutamide
Products Sorafenib is commercially available in the form of film-coated tablets (Nexavar). It has been approved in many countries since 2006. Structure and properties Sorafenib (C21H16ClF3N4O3, Mr = 464.8 g/mol) is present in drugs as sorafenibtosilate, a white to yellowish or brownish powder that is practically insoluble in water. Effects Sorafenib (ATC L01XE05) has antiproliferative, … Sorafenib
Products Panobinostat was approved in many countries in 2015 in capsule form (Farydak). Structure and properties Panobinostat (C21H23N3O2, Mr = 349.4 g/mol) is present in the drug as panobinostat lactate, a white to slightly yellow or brownish powder that is sparingly soluble in water. It is an indole, a hydroxamic acid, and a propenamide derivative. … Panobinostat
Products Tisagenlecleucel (Kymriah, cell suspension for infusion) was approved as the first gene therapy in the United States in 2017 and in the EU and many countries in 2018. The drug was originally developed by Novartis at the University of Pennsylvania. The high price of the therapy is controversial. Mechanism of action Tisagenlecleucel is a … Tisagenlecleucel
Products Rucaparib was approved in tablet form in the United States in 2016, in the EU in 2018, and in many countries in 2020 (Rubraca). Structure and properties Rucaparib (C19H18FN3O, Mr = 323.4 g/mol) is present in the drug as rucaparibcamsylate, a white to slightly yellow powder. Effects Rucaparib has antitumor and cytotoxic properties. The … Rucaparib
Products Erlotinib is commercially available in the form of film-coated tablets (Tarceva). It has been approved in many countries since 2005. Generic versions were registered in 2018. Structure and properties Erlotinib (C22H23N3O4, Mr = 393.4 g/mol) is present in drugs as erlotinib hydrochloride, a white powder that is sparingly soluble in water. Solubility increases with … Erlotinib
Products Rifampicin is commercially available as film-coated tablets, coated tablets, capsules, and injectables (Rimactan, generics). In addition to mono, various combination preparations are also available. Rifampicin has been approved in many countries since 1968. This article refers to peroral monotherapy. Structure and properties Rifampicin (C43H58N4O12, Mr = 823 g/mol) exists as a reddish brown to … Rifampicin
Products Fludarabine is commercially available as an injection/infusion preparation (generic, original: Fludara). It was approved in the United States in 1991 and in many countries in 1995. Structure and properties Fludarabine (C10H12FN5O4, Mr = 285.2 g/mol) or 9-β-D-arabinosyl-2-fluoroadenine is present in drugs as fludarabine phosphate, a white, crystalline, hygroscopic powder that is sparingly soluble in … Fludarabine
Symptoms Possible symptoms include: Fever Large, blotchy skin rash, skin bleeding. Headache, muscle pain Abdominal pain, nausea, vomiting, lack of appetite. Conjunctivitis Vasculitis, hemorrhage, increased blood clotting, blood circulation disorders, encephalitis, organ failure, necrosis. The disease often leads to severe complications and death. It occurs in the United States, Canada and South America. Cause The … Rocky Mountain Spotted Fever
Symptoms In black hairy tongue, a colored, hairy coating appears on the middle and back portions of the tongue. The discoloration can be black, gray, green, brown, and yellow. Itching, burning of the tongue, bad breath, changes in taste, metallic taste, nausea and lack of appetite are other possible symptoms. When swallowed, the “hairs” may … Black Hair Tongue