Products Benfluorex was marketed in many countries as Mediaxal (150 mg, Servier) until 1998. Today, it is no longer on the market. In France and other European countries, it was available as Mediator, among other products. Its approval was not withdrawn in France until 2009, although the risk for cardiotoxic side effects of comparable drugs … Benfluorex
Products In many countries, there are currently no registered medicines containing the active ingredient Cathin. Products containing Cathine are not banned, but are subject to prescription and narcotics laws. Structure D-cathine (C9H13NO, Mr = 151.2 g/mol) is a natural substance from the cath (, Celastraceae), which is also produced synthetically. It is a hydroxylated amphetamine … Cathin
Products Sitaxentan had been on the market in the EU since 2006 in the form of film-coated tablets (Thelin 100 mg, Pfizer). It was withdrawn from the market in 2010 because of liver-toxic side effects. Structure and properties Sitaxentan (C18H15ClN2O6S2, Mr = 454.9 g/mol) is an oxazole, thiophene, benzodioxole, and sulfonamide derivative. It is present … Sitaxentan
Products Tadalafil is commercially available in the form of film-coated tablets (Cialis, Adcirca, generics). It has been approved in many countries since 2004. Generics were registered in 2016 and came on the market in 2019. This article is related to erectile dysfunction treatment. Structure and properties Tadalafil (C22H19N3O4, Mr = 389.4 g/mol) exists as a … Tadalafil
Products Ambrisentan is commercially available in the form of film-coated tablets (Volibris). It has been approved in many countries since 2008. Generic versions were registered in 2020. Structure and properties Ambrisentan (C22H22N2O4, Mr = 378.4 g/mol) is a dimethylpyrimidine, diphenyl and propionic acid derivative and exists as a white crystalline powder that is practically insoluble … Ambrisentan
Products Endothelin receptor antagonists are commercially available in the form of film-coated and dispersible tablets. The first agent in this group to be approved was bosentan (Tracleer) in the United States in 2001 and in the EU and Switzerland in 2002. Effects Antivasoconstrictive Reduce pulmonary and systemic vascular resistance Higher blood flow volume without increasing … Endothelin Receptor Antagonists
Products Macitentan is commercially available in the form of film-coated tablets (Opsumit). It was approved in the United States in October 2013 and in many countries in 2014. Macitentan was launched as a successor to bosentan (Tracleer) as it loses patent protection. Structure and properties Macitentan (C19H20Br2N6O4S, Mr = 588.3 g/mol) is a brominated pyrimidine … Macitentan
Products Sildenafil is commercially available in the form of film-coated tablets and as a solution for injection (Viagra, Revatio, generics). It has been approved in many countries since 1998. Generics went on sale July 22, 2013, and the patent expired June 21. Pfizer launched auto-generic sildenafil Pfizer, identical to the original, back in May. In … Sildenafil
Products Treprostinil is commercially available as an infusion solution (Remodulin, generic). It has been approved in many countries since 2004. Structure and properties Treprostinil (C23H34O5, Mr = 390.5 g/mol) is a synthetic prostacyclin. Effects Treprostinil (ATC B01AC21) has vasodilator and antiplatelet properties. Indications Primary pulmonary hypertension Pulmonary arterial hypertension
Products Finished medicines containing fenfluramine are no longer available in many countries. Ponflural is out of commerce. Fenfluramine has also been combined with phentermine (“fen-phen”). Structure and properties Fenfluramine (C12H16F3N, Mr = 231.3 g/mol) is a fluorinated amphetamine derivative and a racemate. The pure enantiomer dexfenfluramine has also been used medicinally. Effects Fenfluramine (ATC A08AA02) … Fenfluramine
Products Lorcaserin is commercially available in the form of film-coated tablets (Belviq). It was approved in the United States on June 27, 2012. It is not currently registered in many countries. Structure and properties Lorcaserin (C 11 H 14 ClN, M r = 195.7 g/mol) is present in drugs as lorcaserin hydrochloride and hemihydrate, a … Lorcaserin
Products Bosentan is commercially available in the form of tablets and dispersible tablets (Tracleer). It has been approved in many countries since 2002. Generic versions were registered in 2017. Structure and properties Bosentan (C27H29N5O6S, Mr = 551.6 g/mol) is present in drugs as bosentan monohydrate, a white to yellowish powder that is poorly soluble in … Bosentan
