Products Most ACE inhibitors are commercially available in the form of tablets and film-coated tablets. The first agent from this group to be approved was captopril, in many countries in 1980. ACE inhibitors are often combined with the thiazide diuretic hydrochlorothiazide (HCT) fix. Structure and properties ACE inhibitors are peptidomimetics derived from peptides found in … ACE Inhibitors List, Effects, Side Effects
Products Most sartans are commercially available as tablets or film-coated tablets. Losartan was the first agent approved in many countries in 1994 (Cosaar, USA: 1995, Cozaar). Sartans are often combined with hydrochlorothiazide fix. The name of the drug group is derived from the suffix -sartan of the active ingredients. The drugs are also called angiotensin … Sartans
Products Valsartan is commercially available in the form of film-coated tablets and has been approved since 1996 (Diovan, generic). The active ingredient is also combined fixed with other agents: Hydrochlorothiazide (co-Diovan, Exforge HCT with amlodipine, generics). Amlodipine (Exforge, generic). Sacubitril (Entresto) Valsartan scandal: in July 2018, numerous generic drugs had to be recalled from the … Valsartan
Products Perindopril is commercially available in the form of film-coated tablets and has been approved in many countries since 1989 (Coversum N, generic). It is also approved as a fixed combination with indapamide (Coversum N combi, generic) or amlodipine (Coveram, generic). Generic of the fixed combination with amlodipine was first registered in many countries in … Perindopril
Products Drospirenone is commercially available as a fixed combination with ethinyl estradiol for contraception in the form of film-coated tablets (Yasmin, Yasminelle, YAZ, generics, auto-generics). Drospirenone is also used in combination with estradiol for hormone replacement therapy (Angeliq). Bayer’s originals Yasmin, Yasminelle and YAZ will go off the market in many countries in December 2021. … Drospirenone
Products Nesiritide was commercially available in many countries as a powder for the preparation of an infusion solution (Noratak) and had been approved since 2003. Because of a new study of 7141 patients that failed to show a difference between nesiritide and placebo, the product was withdrawn from the market on Dec. 31, 2011 (O’Connor … Nesiritide
Products Losartan is commercially available in the form of film-coated tablets (Cosaar, generics). It has been approved in many countries since 1994 and was the first agent in the sartan group. Losartan is also combined with the diuretic hydrochlorothiazide (Cosaar Plus, generic). Structure and properties Losartan (C22H23ClN6O, Mr = 422.9 g/mol) is a biphenyl, imidazole, … Losartan
Products Irbesartan is commercially available in the form of film-coated tablets as a monopreparation (Aprovel, generic) and as a fixed combination with hydrochlorothiazide (Co-Aprovel). It has been approved in many countries since 1997. Generics entered the market in many countries in August 2012. Generic versions of the combination preprinted with hydrochlorothiazide went on sale in … Irbesartan
Products Aliskiren is commercially available in the form of film-coated tablets (Rasilez, Rasilez HCT + hydrochlorothiazide). It was approved in many countries, in the EU and in the United States in 2007 (Other brand name: Tekturna). Note: Other combination preparations, e.g., with amlodpine (Rasilamlo), are no longer available. Structure and properties Aliskiren (C30H53N3O6, Mr = … Aliskiren
Products Ringer’s solutions are commercially available in many countries as infusion solutions from various manufacturers (e.g., Braun, Bichsel, Fresenius). Irrigation solutions for wound treatment are also available. The solutions are named after the English physician and pharmacologist Sidney Ringer (1835-1910), who discovered in 1883 that the addition of calcium to a saline solution maintains the … Ringer Solutions
Background Potassium ions play an important role in many biological processes, particularly in the generation of membrane and action potentials and electrical conduction in nerve cells and the heart. Potassium is 98% localized intracellularly. The primary active transporter Na+/K+-ATPase provides transport into cells. Two hormones maintain the deep extracellular potassium concentration. The first is insulin, … Hyperkalemia (High Potassium)
Background Potassium ions play an important role in many biological processes, particularly in the generation of membrane and action potentials and electrical conduction in nerve cells and the heart. Potassium is 98% localized intracellularly. The primary active transporter Na+/K+-ATPase provides transport into cells. Two hormones maintain the deep extracellular potassium concentration. The first is insulin, … Hypokalemia (Low Potassium)
