repaglinide

Diabetes Mellitus Type 2: Causes and Treatment

Symptoms The possible acute symptoms of type 2 diabetes include: Thirst (polydipsia) and hunger (polyphagia). Increased urination (polyuria). Visual disturbances Weight loss Fatigue, exhaustion, declining performance. Poor wound healing, infectious diseases. Skin lesions, itching Acute complications: Hyperacidity (ketoacidosis), hyperosmolar hyperglycemic syndrome. Untreated diabetes is far from harmless and can lead in the longer term to … Diabetes Mellitus Type 2: Causes and Treatment

Gemfibrozil

Products Gemfibrozil is commercially available in the form of film-coated tablets (Gevilon, Gevilon Uno). It has been approved in many countries since 1985. Structure and properties Gemfibrozil (C15H22O3, Mr = 250.3 g/mol) exists as a white powder that is practically insoluble in water. Effects Gemfibrozil (ATC C10AB04) has lipid-lowering properties. It lowers VLDL, triglycerides, total … Gemfibrozil

Repaglinide

Products Repaglinide is commercially available in tablet form (NovoNorm, generic). It was approved in many countries in 1999. Structure and properties Repaglinide (C27H36N2O4, Mr = 452.6 g/mol) is a meglitinide and carbamoylmethylbenzoic acid derivative without sulfonylurea structure. It is a white, odorless powder that is practically insoluble in water due to its lipophilicity. In drugs, … Repaglinide

Glinides (Meglitinides): Diabetes Drugs

Products Glinides are commercially available in tablet form. Repaglinide (NovoNorm, USA: 1997) was the first to be approved in many countries in 1999, and nateglinide (Starlix) was approved a year later in 2000. Structure and properties The glinides differ structurally from the sulfonylureas. They are also referred to as meglitinide analogs. Repaglinide is a carbamoylmethylbenzoic … Glinides (Meglitinides): Diabetes Drugs

Nateglinide

Products Nateglinide is commercially available in the form of film-coated tablets (Starlix, Starlix mite). It has been approved in many countries since 2000. Structure and properties Nateglinide (C19H27NO3, Mr = 317.42 g/mol) is a cyclohexane derivative of the amino acid phenylalanine. It is a white powder that is practically insoluble in water. Effects Nateglinide (ATC … Nateglinide

Antidiabetics

Active ingredients Insulins substitute for endogenous insulin: Human insulin Insulin analogues Biguanides reduce hepatic glucose formation: Metformin (Glucophage, generic). Sulfonylureas promote insulin secretion from beta cells: Glibenclamide (Daonil, generic). Glibornuride (Glutril, off label). Gliclazide (Diamicron, generic). Glimepiride (Amaryl, generics) Glinides promote insulin secretion from beta cells: Repaglinide (NovoNorm, generic). Nateglinide (Starlix) Glitazones decrease peripheral insulin … Antidiabetics

Glinide

Synonyms in a broader sense Diabetes drugs, diabetes mellitus, repaglinide (e.g. Novonorm®) and nateglinide (e.g. Starlix®) How do the glinides repaglinide (e.g. Novonorm®) and nateglinide (e.g. Starlix®) work? Repaglinide (Novonorm®) and nateglinide (Starlix®) promote the release of insulin from the pancreas. A prerequisite for this is that the pancreas itself can still produce insulin. When … Glinide

Side effects | Glinide

Side effects As with other oral antidiabetics, gastrointestinal problems such as nausea and vomiting as well as diarrhea or constipation can occur during therapy with repaglinide (Novonorm®) or nateglinide (Starlix®). 10 percent of patients treated with glinides experienced headaches and diffuse visual disturbances, which were attributed to strongly fluctuating blood glucose levels. Under therapy with … Side effects | Glinide

Opicapon

Products Opicapone was approved in the EU in 2016 and in many countries in 2018 in hard capsule form (Ongentys). Structure and properties Opicapone (C15H10Cl2N4O6, Mr = 413.2 g/mol) is an oxadiazole derivative with a pyridine–oxide at position 3. The compound was designed with the goal of developing an effective and safer COMT inhibitor. This … Opicapon

Repaglinide: Effects, Uses & Risks

Repaglinide is an active substance, which is used in the disease diabetes mellitus type 2, when dietary measures, weight reduction and physical training do not sufficiently reduce blood sugar. By inhibiting the potassium channels of the beta cells in the pancreas, the drug leads to the release of insulin. If the dosage and intake conditions … Repaglinide: Effects, Uses & Risks