Products Ranolazine is commercially available in the form of sustained-release tablets (Ranexa). It was approved in the United States as early as 2006, in the EU in July 2008, and in many countries in April 2010. Structure and properties Ranolazine or ()–(2, 6-dimethylphenyl)-4(2-hydroxy-3-(2-methoxyphenoxy)-propyl)-1-piperazine acetamide (C24H33N3O4, Mr = 427.54 g/mol) is a piperazine derivative and a … Ranolazine
Definition/Active substance The active ingredient simvastatin (Simvahexal® from Hexal) is a drug for lowering blood lipid levels. It belongs to the group of so-called HMG-CoA reductase inhibitors (pronouncedly called hydroxy-methylglutaryl coenzyme A reductase inhibitors). This enzyme plays a decisive role in the body’s fat metabolism, as it is essential for the formation of new cholesterol. … Simvastatin
Metabolization The main area of application for simvastatin (Simvahexal®) is mainly hypercholesterolemia, where elevated cholesterol levels are found in the blood. Hypercholesterolemia can be caused by an unhealthy lifestyle, but also by a family genetic predisposition. Another very important field of application is the prevention of cardiovascular diseases, which can be caused by certain diseases … Metabolization | Simvastatin
Interactions Interactions with other drugs occur, for example, when simvastatin (Simvahexal®) is taken at the same time as other fat-lowering drugs such as fibrates. This increases the risk of myopathy or rhabdomyolysis, which can also occur if only the dose of simvastatin is increased. This risk also increases if inhibitors of the enzyme CYP3A4 are … Interactions | Simvastatin
Products Butylated hydroxyanisole is found in numerous drugs as an excipient, for example in semisolid and liquid dosage forms, as well as in tablets and soft capsules. Structure and properties Butylated hydroxyanisole (C11H16O2, Mr = 180.3 g/mol) exists as a white to yellowish or faintly pinkish crystalline powder that is practically insoluble in water. It … Butylhydroxyanisole
Background The human organism has several mechanisms to metabolize endogenous and foreign substances. One of these mechanisms is glucuronidation, which occurs primarily in the liver. In this process, enzymes from the superfamily of UDP-glucuronosyltransferases (UGT) transfer a molecule of glucuronic acid from UDP-glucuronic acid to the substrate. Using acetaminophen as an example, alcohols, phenols, carboxylic … Meulengracht’s Disease
Products Simvastatin is commercially available in the form of film-coated tablets (Zocor, generics). It is also combined fixed with ezetimibe (Inegy, generic). Simvastatin has been approved in many countries since 1990. Structure and properties Simvastatin (C25H38O5, Mr = 418.6 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a … Simvastatin: Drug Effects, Side Effects, Dosage and Uses
Products Sitagliptin is commercially available in film-coated tablet form as a monopreparation (Januvia) and as a fixed combination with metformin (Janumet, Janumet XR). It was approved in many countries in 2007 as the first representative of the gliptins. The combination with simvastatin is not yet registered in many countries (Juvisync). Generics were approved in 2018. … Sitagliptin
Introduction Zocor® is a prescription drug used primarily to lower blood cholesterol levels. It contains the drug simvastatin. Simvastatin in turn belongs to the group of statins. Fields of application: Zocor® is mainly given when there are elevated levels of “bad” LDL cholesterol (hypercholesterolemia) and for the prevention of cardiovascular disease. It is also given … Zocor®
Side effects Side effects are rarely reported while taking Zocor®. Increased liver values (transaminases) may occur. Other side effects may include gastrointestinal problems such as nausea, vomiting, diarrhea (diarrhea) or constipation. Sleeping disorders, depression, non-specific headaches, skin rash or dizziness may also occur. It is important to know that statins and thus also simvastatin can … Side effects | Zocor®
