Definition and properties Tablets are solid dosage forms containing one or more active pharmaceutical ingredients (exception: placebos). They are intended to be taken by mouth. Tablets may be swallowed unchewed or chewed, dissolved in water or allowed to disintegrate before use, or retained in the oral cavity, depending on the galenic form. The Latin term … Tablets
Products Buprenorphine is commercially available as sublingual tablets, transdermal patch and injection solution, and depot injection solution (e.g., Temgesic, Transtec, Subutex, generics). It has been approved in many countries since 1979. Structure and properties Buprenorphine (C29H41NO4, Mr = 467.6 g/mol) is present in drugs as buprenorphine hydrochloride, a white crystalline powder that is sparingly soluble … Buprenorphine
The effect of the first liver passage For a perorally administered pharmaceutical agent to exert its effects at the site of action, it usually must enter the systemic circulation. To do so, it must pass through the intestinal wall, the liver, and part of the circulatory system. Despite complete absorption in the intestine, the bioavailability … First-Pass Metabolism
Introduction Biotransformation is an endogenous pharmacokinetic process that leads to a change in the chemical structure of active pharmaceutical ingredients. The organism’s general goal in doing so is to make the foreign substances more hydrophilic and to direct them to excretion via the urine or stool. Otherwise, they could be deposited in the body and … Metabolism (Biotransformation)
Products Asenapine is commercially available in the form of sublingual tablets (Sycrest). It was approved in many countries in 2012. In the United States, it has been registered since 2009. Structure and properties Asenapine (C17H16ClNO, Mr = 285.8 g/mol) is present in the drug as asenapine maleate. It belongs to the class of dibenzooxepin pyrroles. … Asenapine
Products Nicotine is commercially available in the form of chewing gum, lozenges, sublingual tablets, transdermal patch, oral spray, and inhaler (Nicorette, Nicotinell, generics). The first nicotine replacement product was approved in many countries in 1978. Structure and properties Nicotine (C10H14N2, Mr = 162.2 g/mol) exists as a colorless to brownish, viscous, hygroscopic, volatile liquid that … Nicotine: Drug Effects, Side Effects, Dosage and Uses
Products Uprima sublingual tablets (2 mg, 3 mg) for erectile dysfunction are no longer marketed in many countries. The marketing authorization was not renewed by Abbott AG in 2006. Commercial reasons were cited, probably attributed to competition from phosphodiesterase-5 inhibitors (e.g., sildenafil, Viagra). It is also possible that a post-marketing study had played a role, … Apomorphine
Definition and properties The administration or application of a drug refers to its use on the body. The dosage forms (drug forms) used for this purpose consist of the active ingredients and excipients. These include, for example, tablets, capsules, solutions, syrups, injectables, creams, ointments, eye drops, ear drops, and suppositories. Drugs can be liquid, semi-solid, … Administration
Products Fentanyl is commercially available in many countries in the form of lozenges, buccal tablets, sublingual tablets, as a fentanyl patch (e.g., Durogesic, generic), and as a solution for injection. It is a narcotic and is subject to enhanced prescription requirements. Structure and properties Fentanyl (C22H28N2O, Mr = 336.5 g/mol) exists as a white powder … Fentanyl: Drug Effects, Side Effects, Dosage and Uses
Products Solutions and sublingual tablets are available for sublingual immunotherapy in many countries (e.g., Oralair, Staloral, Grazax). Sublingual tablets, unlike some solutions, do not need to be stored in the refrigerator. Ingredients The medicines contain allergen extracts of common allergens, such as pollen from grasses, trees, and shrubs. Effects The allergen extracts (ATC V01AA) produce … Sublingual Immunotherapy
Products Sufentanil is commercially available as a solution for injection (Sufenta, generic). It was developed in the 1970s and has been approved in many countries since 1994. Sublingual tablets for pain management are also available in some countries (Dzuveo, Zalviso). Structure and properties Sufentanil (C22H30N2O2S, Mr = 386.6 g/mol) is present in drugs as sufentanil … Sufentanil
Symptoms Breakthrough pain is acute and transient pain that occurs against a background of continuous pain management. It is an acute exacerbation that is most common in chronic disease and especially in cancer. The pain is usually sudden, acute, and intense. Causes The exact causes are not always known. Breakthrough pain may occur as a … Breakthrough Pain
