tazobactam

Penicillins

Products Penicillins are commercially available today in the form of film-coated tablets, capsules, as solutions for injection and infusion, as powders for preparing an oral suspension, and as syrups, among others. Penicillin was discovered in September 1928 at St. Mary’s Hospital in London by Alexander Fleming. He was working with staphylococcal cultures in Petri dishes. … Penicillins

Tazobactam: Effects, Uses & Risks

The drug tazobactam is a beta-lactamase inhibitor and supports and enhances the antibacterial effect of the beta-lactam antibiotic piperacillin without being antibiotically active itself. Tazobactam irreversibly binds to the enzyme beta-lactamase, which is produced by some pathogenic bacteria and can inactivate beta-lactamase antibiotics. Because of its binding properties, tazobactam is used exclusively in combination with … Tazobactam: Effects, Uses & Risks

Combination Products

Definition Drugs today usually contain a defined active pharmaceutical ingredient. However, numerous drugs with two or more active substances also exist. These are called combination drugs or fixed combinations. For example, Aspirin C contains both acetylsalicylic acid and vitamin C. Many blood pressure medications are combination preparations, for example perindopril + indapamide or candesartan + … Combination Products

Tazobactam

Products Tazobactam is commercially available as a fixed combination with piperacillin as an injectable (Tazobac, generics). It has been approved in many countries since 1992. In 2016, a combination with ceftolozane was released (Zerbaxa). Structure and properties Tazobactam (C10H12N4O5S, Mr = 300.3 g/mol) is a triazolylmethylpenicillic acid sulfone present in drugs as tazobactam sodium. Effects … Tazobactam

Ceftolozan

Products Ceftolozane was approved in the United States in 2014, in the EU in 2015, and in many countries in 2016 as an infusion preparation in fixed combination with tazobactam (Zerbaxa). Structure and properties Ceftolozane (C23H30N12O8S2, Mr = 666.7 g/mol) is present in the drug as ceftolozane sulfate. Effects Ceftolozane (ATC J01DI54) has bactericidal properties. … Ceftolozan

Piperacillin

Products Piperacillin is commercially available as an injectable (tazobac + tazobactam, generics). It has been approved in many countries since 1992. Structure and properties Piperacillin (C23H27N5O7S, Mr = 517.6 g/mol) is present in drugs as piperacillin sodium, a white crystalline powder that is readily soluble in water. Tazobactam (C10H12N4O5S, Mr = 300.3 g/mol) also exists … Piperacillin

Antibiotics for pneumonia

Introduction Pneumonia is almost always caused by a bacterial infection. The pathogens are transmitted by coughing or sneezing and cause an inflammation of the lower respiratory tract. The most common triggers include pneumococcus in adults, and bacteria of the genus Haemophilus influenzae type b and Staphylococcus aureus in small children. Bacterial pneumonia is usually treated … Antibiotics for pneumonia

Which antibiotic is the best? | Antibiotics for pneumonia

Which antibiotic is the best? In the case of pneumonia, the drug of choice is an antibiotic from the group of aminopenicillins (e.g. amoxicillin). However, which antibiotic works best in pneumonia depends on the patient’s age and concomitant diseases, his nicotine and alcohol consumption and the severity and cause of the infection. The most suitable … Which antibiotic is the best? | Antibiotics for pneumonia

Is it still contagious if you take antibiotics? | Antibiotics for pneumonia

Is it still contagious if you take antibiotics? The antibiotic kills the bacteria in the body or prevents them from multiplying. This improves the symptoms and the infection heals. Nevertheless, there are still living bacteria in the lungs for the duration of taking the antibiotic and patients are still potentially infectious. Can pneumonia be treated … Is it still contagious if you take antibiotics? | Antibiotics for pneumonia