The active ingredient terbinafine is used to treat fungal diseases. The agent can be used both topically and systemically. What is terbinafine? The antifungal agent is mainly used for the treatment of athlete’s foot (tinea pedis) and nail fungus (onychomycosis). Terbinafine is an allylamine derivative, which is one of the antifungal agents. The antifungal agent … Terbinafine: Effects, Uses & Risks
Symptoms Athlete’s foot (tinea pedis) usually develops between the toes and manifests as sometimes severe itching, burning, reddening of the skin, white softened, peeling and torn skin, skin blisters and dry skin. The symptoms also occur on the soles of the feet and are accompanied by hyperkeratosis. In the course, a difficult-to-treat nail fungus may … Athlete’s Foot
The effect of the first liver passage For a perorally administered pharmaceutical agent to exert its effects at the site of action, it usually must enter the systemic circulation. To do so, it must pass through the intestinal wall, the liver, and part of the circulatory system. Despite complete absorption in the intestine, the bioavailability … First-Pass Metabolism
Products Naftifine is commercially available as a gel and cream for external use. The drug has not yet been registered in many countries. Structure and properties Naftifine (C21H21N, Mr = 287.4 g/mol) is a lipophilic naphthalene derivative and belongs to the group of allylamines, which includes terbinafine. In pharmaceuticals, it is present as naftifine hydrochloride. … Naftifine
Symptoms A nail fungus manifests as a white to yellow-brown discoloration of the nail, thickening, softening and deformation. The most common form of nail fungus is the so-called distal-lateral subungual onychomycosis, which often occurs on the big toe. In this case, the fungus grows into the nail bed at the outer end and laterally at … Nail Fungus Causes and Treatment
Products Antifungal products are commercially available as creams, ointments, powders, solutions, tablets, capsules, and injectables, among others. Structure and properties The antifungal agents are a structurally heterogeneous class of agents. However, several groups can be identified within the antifungals, such as the azole antifungals and the allylamines (see below). Effects Antifungals have antifungal, fungistatic, or … Antifungals
Symptoms Typical symptoms of agranulocytosis include fever, chills, feeling ill, tonsillitis, sore throat, difficulty swallowing, and lesions and bleeding of the oral, nasal, pharyngeal, genital, or anal mucosa. The disease can lead to dangerous infections and blood poisoning and, if left untreated, can relatively often be fatal. Agranulocytosis usually occurs rarely to very rarely as … Agranulocytosis Symptoms and Treatment
Symptoms Pityriasis versicolor is a skin disorder that occurs primarily on areas with high sebum production, such as the back, chest, upper arms, shoulders, armpits, neck, face, and scalp. Round to oval hyper- or hypopigmented patches occur. The skin is slightly thickened, scaly, and sometimes mildly itchy. The patches may be colored, for example, pink, … Pityriasis Versicolor: Medicinal Uses
Products Butenafine is not commercially available in many countries. In other countries, it is available as a cream (e.g., Mentax) and other products. Structure and properties Butenafine (C23H27N, Mr = 317.5 g/mol) is present in drugs as butenafine hydrochloride, a white crystalline powder that is sparingly soluble in water. It is a naphthalene derivative and … Butenafine
Symptoms In areas with high sebum production and hair formation: scalp, eyebrows, eyelashes, between eyelashes, beard and moustache region, behind the ear, on the ear, next to the nostrils, chest, around the belly button, genitoanal region Skin redness, typically symmetrical Greasy or powdery head dandruff Itching and burning Seborrhea Oily scaly skin Comorbidities: Acne, abscess, … Seborrheic Dermatitis
Products Terbinafine cream has been approved in many countries since 1991 (Lamisil, generic). Structure and properties Terbinafine (C21H25N, Mr = 291.43 g/mol) is present in the drug as terbinafine hydrochloride, a white crystalline powder that is sparingly soluble in water. It belongs structurally to the allylamines. Effects Terbinafine (ATC D01AE15) has fungistatic to fungicidal properties … Terbinafine Cream
Terbinafine is a commonly used drug used to treat fungal diseases. Like the antifungal drug naftifine, it has an inhibitory effect on an enzyme that is important for fungal reproduction. This suppresses the growth of the fungi. Terbinafine can be taken as an ointment on the skin or orally as a tablet. Side effects may … Terbinafine: Effect and Side Effectsive against Fungal Diseases
