Products Trametinib was approved in the form of film-coated tablets in the United States in 2013, in the EU in 2014, and in many countries in 2016 (Mekinist). Structure and properties Trametinib (C26H23FIN5O4, Mr = 615.4 g/mol) is a pyridine and a pyrimidine derivative. It is present in the drug product as trametinib dimethyl sulfoxide, … Trametinib
Products Cobimetinib is commercially available in the form of film-coated tablets (Cotellic). It was approved in many countries in 2015. Structure and properties Cobimetinib (C21H21F3IN3O2, Mr = 531.3 g/mol) is present in the drug as cobimetinib hemifumarate, a white crystalline substance whose solubility is pH-dependent. Effects Cobimetinib (ATC L01XE38) has antitumor and antiproliferative properties. The … Cobimetinib
Background Kinases (phosphotransferases) are a large family of enzymes involved in the transduction and amplification of signals on and in cells. They exert their effects by phosphorylating their substrates, that is, by adding a phosphate group to the molecules (Figure). Kinases have complicated names that are usually abbreviated: ALK, AXL, BCR-ABL, c-Kit, c-Met, ERBB, EGFR, … Kinase Inhibitors
Symptoms Melanomas are discolored, growing, skin lesions that arise from pigmented moles in about 30% of cases. They are found primarily on the skin, but can occur anywhere melanocytes are found, including the oral mucosa, respiratory tract, or eye, for example. In men they are most common on the upper body, in women on the … Melanoma Causes and Treatment
Products Vemurafenib was approved in 2011 in film-coated tablet form (Zelboraf). Structure and properties Vemurafenib (C23H18ClF2N3O3S, Mr = 489.9 g/mol) is a white, crystalline substance that is practically insoluble in water. Effects Vemurafenib (ATC L01XE15) has antitumor and antiproliferative properties. It reduces mortality and increases survival. The properties are based on inhibition of the mutant … Vemurafenib
Definition Instructions to take a drug fasting usually mean to administer it at least one-half to one (or even two) hours before or no earlier than two hours after eating. The full details can be found in the patient information leaflet and in the specialist information leaflet. This is why it is also referred to … Sober
Products Dabrafenib was approved in the US and EU in 2013 and in many countries in 2014 in hard capsule form (Tafinlar). Structure and properties Dabrafenib (C23H20F3N5O2S2, Mr = 519.6 g/mol) is present in drugs as dabrafenib mesilate, a white to slightly colored powder that is practically insoluble in water. It is a thiazole and … Dabrafenib
Background Medicines are usually stored at room temperature between 15 to 25 °C (sometimes up to 30 °C). However, for relatively many drugs, storage in the refrigerator at a temperature between 2 to 8 °C is mandatory. Why? At a low temperature, the molecular movement and reactivity of the compounds is reduced, germ growth is … Store Cool
