Products Eflornithine is commercially available as a cream in many countries and has been approved since 2003 (Vaniqa). Vaniqa was released in the United States in 2000 and in the EU in 2001. Structure and properties Eflornithine (C6H12F2N2O2, Mr = 182.2 g/mol) is a fluorinated and methylated derivative of the amino acid ornithine. It is … Eflornithine
Products No finished drug products containing nifurtimox are on the market in many countries. Lampit is not approved in many countries. Structure and properties Nifurtimox (C10H13N3O5S, Mr = 287.3 g/mol) is a nitrofuran derivative. Effects Nifurtimox (ATC P01CC01) has antiparasitic properties. The effects are due to the formation of free radicals. Indications For the treatment … Nifurtimox
Products Fexinidazole is about to be approved by the EMA in 2018 in tablet form (Fexinidazole Winthrop). This is the first new approval in this field in decades. For the first time, a peroral therapy is available. The drug has been developed since 2005 in a collaboration between DNDi (Drugs for Neglected Diseases initiative), Sanofi … Fexinidazole
Products Pentamidine is commercially available as a dry substance for injection or inhalation (pentacarinate). It has been approved in many countries since 1990. Structure and properties Pentamidine (C19H24N4O2, Mr = 340.4 g/mol) is an aromatic diamidine. It exists as a pentamidine diisetionate, a white powder or colorless crystals that are readily soluble in water. Effects … Pentamidine
Effect Nitroimidazoles are antibacterial (bactericidal) and antiparasitic. They are reduced under anaerobic conditions to cytotoxic metabolites that covalently bind to and damage DNA. The damage may take the form of loss of helical structure, impaired matrix function, or strand breaks, leading to inhibition of DNA synthesis. Indications Spectrum: gram-positive and gram-negative anaerobic bacteria and some … Nitroimidazole
Symptoms Possible symptoms of African trypanosomiasis (sleeping sickness) in the first stage include: Nodule or ulcer on the skin at the bite site (trypanosome chancre). Feeling sick, fatigue, weight loss. Fever with chills Headache, joint pain Skin rash Swollen lymph nodes Organ diseases (eg, heart, liver, spleen). In the first stage, trypanosomes are in the … Trypanosomiasis
Every one of us has had it at one time or another: leaden fatigue and an extreme need for sleep. Especially during the dreary winter months, the desire to simply pull the covers over our heads sometimes in the morning and allow our bodies and minds to rest is strong. “I’ve got the sleeping sickness” … What does Sleeping Sickness Mean?
