Antiparasitic therapy with the drug spiramycin (until the 16th week of gestation (SSW)) or with the combination of pyrimethamine + sulfadiazine + folinic acid (from the 16th SSW) for at least four weeks.
If therapy begins within the first four weeks, only circa 15% of infected infants have clinical manifestations. Initiation of therapy after the eighth week results in clinical symptoms in 70% of cases. In the absence of therapy, approximately 85% of infected children show severe clinical symptoms.
The duration of treatment depends on the severity of the disease. In retinochorioiditis (posterior uveitis/posterior choroid), clindamycin (lincosamide) is an alternative to combination therapy. Postnatally (after birth) acquired toxoplasmosis does not require therapy.
