Viral Meningitis: Or something else? Differential Diagnosis

Cardiovascular (I00-I99).

  • Subarachnoid hemorrhage (SAB; hemorrhage between the cribriform meninges and the soft meninges; incidence: 1-3%); symptomatology: proceed according to “Ottawa rule for subarachnoid hemorrhage”:
    • Age ≥ 40 years
    • Meningismus (symptom of painful neck stiffness in irritation and disease of the meninges).
    • Syncope (brief loss of consciousness) or impaired consciousness (somnolence, sopor and coma).
    • Onset of cephalgia (headache) during physical activity.
    • Thunderclap headache/destructive headache (about 50% of cases).
    • Restricted mobility of the cervical spine (Cervical spine).

Infectious and parasitic diseases (A00-B99).

  • Rocky Mountain spotted fever (RMSF; Rocky Mountain spotted fever) – most common and most severe disease caused by rickettsia (bacterium Rickettsia rickettsii) in the United States.
  • Cerebral malaria (consider when entering the country from sub-Saharan Africa) – occurrence in approximately1% of patients with P. falciparium malaria – especially in children in sub-Saharan Africa; symptomatology: headache with general malaise; in children often accompanied by characteristic changes in the retina (so-called malaria retinopathy); furthermore, neurological focal symptoms such as paralysis and seizures, as well as coma; until death by respiratory arrest usually pass only 24 hours; despite treatment, about 15-20% of patients die; most fatalities are children under five years.

Neoplasms – tumor diseases (C00-D48).

  • Meningeosis carcinomatosa – metastases of a tumor disease in the meninges.
  • Rupture of a tumor cyst – bursting of a cavity (cyst) filled with malignant cells (cancerous disease).

Psyche – nervous system (F00-F99; G00-G99).