What role does histamine play in allergies? | Allergy symptoms

What role does histamine play in allergies?

Histamine is one of the most decisive messengers or mediators in allergies. When the body comes into contact with a substance to which it is hypersensitive for the first time, a process known as sensitization occurs. The B cells, an important part of the immune system, form IgE antibodies after activation by certain messenger substances.

These IgE antibodies bind to the body’s own immune system cells, including mast cells. If the body now comes into contact with the allergen again, the binding of the allergen to the IgE-antibodies, which are located on the mast cells among other things, leads to the so-called mast cell degranulation. This means that the mast cells release their contents into the bloodstream.

One of the most important ingredients of the mast cells is histamine. Histamine leads to numerous allergy-typical symptoms such as In addition to histamine, other messenger substances such as leukotrienes and prostaglandins also play an important role in the development of allergy symptoms. – skin rash,

  • Itching and
  • A narrowing of the bronchial muscles, which plays a major role in allergic asthma.