Malignant Fibrous Histiocytoma: Drug Therapy Therapeutic targets Removal of the tumor – see “Surgical therapy“. Healing Therapy recommendations Analgesia according to WHO staging scheme: Non-opioid analgesic (paracetamol, first-line agent). Low-potency opioid analgesic (e.g., tramadol) + non-opioid analgesic. High-potency opioid analgesic (eg, morphine) + non-opioid analgesic. Malignant fibrous histiocytoma is not very sensitive to radiation. Nevertheless, postoperative radiotherapy (radiotherapy) reduces the formation of local recurrence (recurrence of the disease). If necessary, chemotherapy