Medical history (history of illness) represents an important component in the diagnosis of malignant fibrous histiocytoma (MFH). Family history Are there any diseases in your family that are common? (Tumor diseases) Social anamnesis Current medical history/systemic history (somatic and psychological complaints). Do you suffer from persistent or increasing pain for which there is no identifiable … Malignant Fibrous Histiocytoma: Medical History
Musculoskeletal system and connective tissue (M00-M99). Fibrous dysplasia – malformation of bone tissue, that is, the bones form tumor-like projections. Bone infarction (demise of bone tissue). Paget’s disease (osteodystrophia deformans) – bone disease that leads to bone remodeling and gradually thickening of several bones, usually the spine, pelvis, extremities or skull. Osteomyelitis – acute or … Malignant Fibrous Histiocytoma: Or something else? Differential Diagnosis
The following are the major diseases or complications that may be contributed to by malignant fibrous histiocytoma (MFH): Neoplasms – Tumor Diseases (C00-D48). Metastasis (daughter tumors) – especially pulmonary (“to the lungs”; 90%), rarely osseous (“to the bones“; 8%) or hepatogenous (“to the liver“; 1%). Psyche – Nervous System (F00-F99; G00-G99). Depression Further Functional disorders … Malignant Fibrous Histiocytoma: Complications
According to localization, malignant fibrous histiocytoma (MFH) is classified as follows: Retroperitoneal type (retroperitoneum = space located behind the peritoneum on the back toward the spine). MFH of the extremities (along the muscles and fascia). Dermal/cutaneous (affecting the skin) sarcoma. Histologically, the following types can be separated from the original group of malignant fibrous histiocytomas … Malignant Fibrous Histiocytoma: Classification
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body temperature, body weight, body height; furthermore: Inspection (viewing). Skin and mucous membranes [often broad ulcerated (“ulcerated”) nodule in cutis (skin) and subcutis (subcutis) (palpable) – usually painless/poor] Neck Extremities: [swelling? Size; consistency; displaceability of … Malignant Fibrous Histiocytoma: Examination
1st order laboratory parameters – obligatory laboratory tests. Biopsy (tissue sample) – characteristic of malignant fibrous histiocytoma is pleomorphy (nuclei of similar cells take on a different appearance): the cells resemble a fibroblast (connective tissue cell) on the one hand and a histiocyte (resident phagocyte) on the other. Caveat: Because other sarcomas also contain pleomorphic … Malignant Fibrous Histiocytoma: Test and Diagnosis
Therapeutic targets Removal of the tumor – see “Surgical therapy“. Healing Therapy recommendations Analgesia according to WHO staging scheme: Non-opioid analgesic (paracetamol, first-line agent). Low-potency opioid analgesic (e.g., tramadol) + non-opioid analgesic. High-potency opioid analgesic (eg, morphine) + non-opioid analgesic. Malignant fibrous histiocytoma is not very sensitive to radiation. Nevertheless, postoperative radiotherapy (radiotherapy) reduces the … Malignant Fibrous Histiocytoma: Drug Therapy
Obligatory medical device diagnostics. Conventional radiography of the affected body region, in two planes – to assess the extent of tumor growth; malignant (malignant) fibrous histiocytoma is usually well demarcated and may contain calcifications Computed tomography (CT; cross-sectional imaging (radiographs taken from different directions with computer-based evaluation)) – for the purpose of determining tumor location, … Malignant Fibrous Histiocytoma: Diagnostic Tests
In malignant fibrous histiocytoma (MFH), removal in healthy individuals with a safety margin is the goal. The following form of surgical therapy is performed: Wide resection – method of choice for malignant bone tumors. Procedure: wide and radical resection (surgical removal) of the tumor with a safety margin. After tumor removal, osteosynthesis (insertion of a … Malignant Fibrous Histiocytoma: Surgical Therapy
The clinical presentation of malignant fibrous histiocytoma (MFH) is not very characteristic. In the extremities, MFH appears as a painless mass. If a malignant fibrous histiocytoma develops in the retroperitoneum (space that lies behind the peritoneum on the back in the direction of the spine), it can spread unnoticed for a long time. Only when … Malignant Fibrous Histiocytoma: Symptoms, Complaints, Signs
Pathogenesis (disease development) Malignant fibrous histiocytoma (MFH) is a fibrohistiocytic tumor, meaning that the cells resemble a fibroblast (connective tissue cell) on the one hand and a histiocyte (resident phagocyte) on the other. Thus, a pleomorphic (multiform) appearance is present. The tumor arises from mesenchymal tissue (mesenchyme = part of the embryonic connective tissue). This … Malignant Fibrous Histiocytoma: Causes
General measures Nicotine restriction (refraining from tobacco use). Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Limited caffeine consumption (max 240 mg of caffeine per day; equivalent to 2 to 3 cups of coffee or 4 to 6 cups of green/black tea). Aim for normal weight! … Malignant Fibrous Histiocytoma: Therapy
