Aminorex

Products

Aminorex was approved in many countries in 1965 and withdrawn from the market in 1972 due to adverse effects (Menocil).

Structure and properties

Aminorex (C₉H₁₀N₂O, M_r = 162.2 g/mol) is a dihydrooxazolamine structurally related to amphetamines.

Effects

Aminorex has appetite suppressant properties. The effects are due to the release of catecholamines.

Indications

For the treatment of overweight and obesity.

Abuse

The derivative 4-methylaminorex (“Euphoria”) is abused as an illegal narcotic.

Adverse effects

The drug has led to an increase in cases of pulmonary arterial hypertension and caused numerous deaths during the years of its approval.