Estimate the risk of thrombosis in a genetic test? | Genetic test – When is it useful?

Estimate the risk of thrombosis in a genetic test?

The development of thrombosis is always multifactorial. Important influences on the development of thrombosis are low mobility, reduced blood flow in the veins, severe fluid deficiency and an increased tendency to thrombosis due to different blood compositions. Numerous components in the blood can be altered, which can lead to a tendency to thrombosis.

These include genetic factors that lead to increased clotting in some people. There are various congenital diseases of the blood clotting system that greatly increase the risk of thrombosis. The most important of these are the testing of: APC resistance (factor V Leiden mutation) The most common genetic disease with a tendency to thrombosis is APC resistance, which is triggered by a so-called “factor V Leiden mutation”. Prothrombin mutation Antithrombin mutation Mutation of protein C or S (e.g. protein S deficiency) If you suspect a hereditary disease, you should seek clarification in cases of familial accumulation or thromboses at a young age that are recurrent or occur in untypical locations such as the arm.

• APC resistance (factor V Leiden mutation) The most common genetic disease with a tendency to thrombosis is APC resistance, which is triggered by a so-called “factor V Leiden mutation”.
• Prothrombin Mutation
• Antithrombin mutation
• Mutation of protein C or S (e.g. protein S deficiency)

Alternatives to genetic testing

Depending on what exactly is to be tested, one can try to find alternative ways of diagnosing existing diseases in order to detect them. Unfortunately, there is no alternative to genetic testing if you want to find out if you have an increased risk for a specific disease. So for anything that would be a prediction, genetic testing would have to be performed.

The other possibility would be to refrain from genetic testing. Many people decide against a genetic test despite family history or other risk factors in order not to burden themselves psychologically with a possible diagnosis. In general, it is always sensible to undergo preventive medical checkups in order to detect tumors or other diseases at an early stage.