Flank Pain: Or something else? Differential Diagnosis

Cardiovascular (I00-I99).

  • Ruptured aortic aneurysm (outpouching of the aorta that has ruptured) – usually left-sided rupture with continuous pain (annihilation pain) and tendency to collapse; possible additional symptoms: diffuse abdominal and back pain, a poorly palpable inguinal pulse of variable intensity, and dizziness (older patients)

Liver, gallbladder, and bile ducts-pancreas (pancreas) (K70-K77; K80-K87).

Mouth, esophagus (esophagus), stomach and intestines (K00-K67; K90-K93).

Musculoskeletal system and connective tissue (M00-M99)

  • Facet syndrome (synonym: facet joint syndrome) – pseudoradicular pain symptomatology (pain in which the nerve itself is not affected in its function), usually caused by chronic irritation of the so-called facet joints (zygapophyseal joints; intervertebral joints: small, paired joints that exist between the articular processes (processus articularis) of adjacent vertebrae and ensure the mobility of the spine).
  • Musculoskeletal pain from the level Th 10-12.

Neoplasms – tumor diseases (C00-D48)

  • Urinary bladder carcinoma (cancer of the urinary bladder; urinary obstruction).
  • Testicular carcinoma (testicular cancer; retroperitoneal metastasis).
  • Hypernephroma (renal cell carcinoma).
  • Pheochromocytoma – neuroendocrine (affecting the nervous system) catecholamine-producing tumor of the chromaffin cells of the adrenal medulla (85% of cases) or sympathetic ganglia (nerve cord that runs along the spine in the thoracic (chest) and abdominal (stomach) regions) (15% of cases)
  • Prostate carcinoma (prostate cancer; lymph nodes obstructing the ureters).

Pregnancy, childbirth, and puerperium (O00-O99).

  • Extrauterine pregnancy – implantation of the fertilized egg outside the uterus (womb) such as: Tubalgravidity (tubal pregnancy), Ovariangravidity (pregnancy in the ovary), Peritonealgravidity/Abdominalgravidity (abdominal pregnancy), or Cervicalgravidity (a pregnancy in the cervix).
  • Pregnancy – acute flank pain develops in approximately 3% of all pregnant women; upper urinary tract infections (pyelonephritis) are the most common.

Psyche – nervous system (F00-F99; G00-G99).

Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99).

  • Dysmenorrhea (menstrual pain).
  • Glomerulonephritis – kidney disease associated with inflammation of the renal corpuscles (glomerulum, plural glomeruli or glomerula, corpuscula renales) in the kidney
  • Urinary tract infection (UTI)
  • Hydronephrosis – dilation of the renal cavity system, which in the medium and long term is associated with destruction of kidney tissue.
  • Nephrolithiasis (kidney stones)
  • Ovarian cyst (ovarian cyst), pedunculated.
  • Ovulation pain (pain caused by ovulation).
  • Pyelonephritis (inflammation of the renal pelvis; upper urinary tract infection).
  • Urolithiasis (urinary stones; 30-60 years).
  • Cystic kidney disease

All diagnoses that can explain abdominal pain are also among the important differential diagnoses of flank pain.