Medical history (history of illness) represents an important component in the diagnosis of osteoblastoma. Family history Are there any diseases in your family that are common? (Tumor diseases) Social anamnesis Current medical history/systemic history (somatic and psychological complaints). Do you suffer from persistent or increasing pain in the skeletal system for which there is no … Osteoblastoma: Medical History
Once osteoblastomas cause symptoms, they must be resected (surgically removed).The challenge in the surgical procedure is hitting the nidus in the bone sclerosis that may be present. The nidus must be completely removed. It is responsible for the pain. The bone sclerosis is left behind. Damage to muscles, tendons, soft tissues and also nerves located … Osteoblastoma: Surgical Therapy
The following symptoms and complaints may indicate osteoblastoma: Main symptoms Little pain – dull ache; unlike the comparable osteoid osteoma, does not necessarily occur at night; because the vertebrae are often involved, the pain is often localized in the back Neurological symptoms such as numbness and paresis (paralysis) – as a sign of compression of … Osteoblastoma: Symptoms, Complaints, Signs
Pathogenesis (disease development) Osteoblastomas originate from osteoblasts (bone-forming cells) and thus are classified as osseous tumors. Their nidus (focus) is between 1.5 and 2 cm (even > 2 cm) in size, making it larger than the comparable osteoid osteoma (< 1.5 cm). It is a well-vascularized (vascularized/strongly vascularized) area. In contrast to osteoid osteoma, reactive … Osteoblastoma: Causes
Musculoskeletal system and connective tissue (M00-M99). Aneurysmal bone cyst (AKZ) – tumor-like osteolytic lesions (“bone loss”) with dark red to brownish cavities up to 14 cm3 in size. Fibrous dysplasia – malformation of bone tissue, that is, the bones form tumor-like protrusions; especially the inner nose and paranasal sinuses. Neoplasms – tumor diseases (C00-D48). Epidural … Osteoblastoma: Or something else? Differential Diagnosis
The following are the most important diseases or complications that may be contributed to by osteoblastoma: Musculoskeletal system and connective tissue (M00-M99). Restricted mobility Incorrect load and joint misalignment, postural deformities (caused by the pain → avoidance behavior). When osteoblastoma is located near joints or growth plates: Osteoarthritis (joint wear and tear). Scoliosis (lateral curvature … Osteoblastoma: Complications
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin and mucous membranes Extremities: [swelling? Deformities of joints and bones? Sensory disturbances?] Spine, thorax (chest). Gait pattern (fluid, limping) Body or joint posture (upright, bent, gentle posture). Malpositions … Osteoblastoma: Examination
1st order laboratory parameters – obligatory laboratory tests. Biopsy (tissue sample), if necessary – to confirm the diagnosis.
Therapeutic targets Relief of pain Removal of the tumor – see “Surgical Therapy“. Healing Therapy recommendations Unlike osteoid osteomas, osteoblastomas do not respond to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) such as salicylates, e.g., acetylsalicylic acid! About the administration of cyclooxygenase inhibitors (COX-2 inhibitors) can inhibit the synthesis (production) of prostaglandins (= tissue hormone that … Osteoblastoma: Drug Therapy
Obligatory medical device diagnostics. Conventional radiography of the affected body region, in two planes – to assess the extent of tumor growth; detection of osteolytic (bone-dissolving) areas (usually > 2 cm). Computed tomography (CT; sectional imaging method (X-ray images from different directions with computer-based evaluation)) – for the purpose of determining the location, size, and … Osteoblastoma: Diagnostic Tests
General measures Nicotine restriction (refraining from tobacco use). Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Limited caffeine consumption (max 240 mg of caffeine per day; equivalent to 2 to 3 cups of coffee or 4 to 6 cups of green/black tea). Aim for normal weight! … Osteoblastoma: Therapy
