Pathogenesis (development of disease) After uptake into the body, human herpes virus type 6B predominantly infects T lymphocytes (T cells; cells that play an important role in the human immune system). The virus persists throughout life and apparently always remains productive. Etiology (causes) Behavioral causes Transmission by droplet infection or saliva.
Babies with fever generally belong to the pediatrician. Older children should be presented to a physician in the following cases: The fever rises above 38.5 °C. The child refuses to drink, loses fluid and becomes dehydrated. The child is well, but vomiting lasts longer than twelve hours (if the child is not well, earlier to … Three-Day Fever (Exanthema Subitum): Therapy
Medical history (history of illness) represents an important component in the diagnosis of exanthema subitum (three-day fever). Family history What is the general health of your relatives? Social anamnesis Current medical history/systemic medical history (somatic and psychological complaints). What symptoms have you noticed? Is there a fever present? If so, how long has it been … Three-Day Fever (Exanthema Subitum): Medical History
Skin and subcutaneous (L00-L99). Drug exanthema – rash due to allergic reactions to various drugs. Infectious and parasitic diseases (A00-B99). Enterovirus infections Erythema infectiosum (ringworm) Morbilli (measles) Rubella (rubella) Scarlatina (scarlet fever)
The following are the major diseases or complications that may be contributed to by human herpes virus type 6B: Infectious and parasitic diseases (A00-B99). Immunosuppression may lead to reactivation of the virus with severe infections such as pneumonia (pneumonia) or encephalitis (encephalitis); in organ transplantation, this may lead to rejection reactions
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin, mucous membranes, and sclerae (white part of the eye) [exanthema (rash) with large pale red spots (after fever subsides)] Abdomen (abdomen) Shape of the abdomen? Skin color? Skin … Three-Day Fever (Exanthema Subitum): Examination
2nd order laboratory parameters – depending on the results of the history, physical examination, etc. – For differential diagnostic clarification Culture of the virus from pharyngeal lavage water or saliva. Nucleic acid detection in the PCR Serological detection of IgG/IgM antibodies against herpes virus type 6 (HHV6).
Therapeutic targets Symptom relief Avoidance of complications Therapy recommendations Symptomatic therapy (antipyretics (antipyretic drugs) such as acetaminophen; for febrile convulsions, anticonvulsant (“anti-convulsant”) drugs such as diazepam). Virostase (antivirals) only in immunocompromised patients (due tohigh risks of complications). See also under “Further therapy“.
Optional medical device diagnostics – depending on the results of the history, physical examination, laboratory diagnostics, and obligatory medical device diagnostics – for differential diagnostic clarification. If reactivation is suspected, depending on the exact symptoms, sonography (ultrasound examination), conventional X-ray examination; in rare cases, if necessary, computed tomography (CT; sectional imaging procedure (X-ray images from … Three-Day Fever (Exanthema Subitum): Diagnostic Tests
To prevent exanthema subitum (three-day fever), attention must be paid to reducing risk factors. Behavioral risk factors Transmission by droplet infection or saliva.
The following symptoms and complaints may indicate exanthema subitum (three-day fever): Leading symptoms Rapid rise in fever – a febrile convulsion is also possible. Respiratory symptoms such as cough or gastrointestinal symptoms such as diarrhea (diarrhea) may occur during the fever phase After the fever has subsided, an exanthema (rash) with large pale red spots … Three-Day Fever (Exanthema Subitum): Symptoms, Complaints, Signs
