Systemic Inflammatory Response Syndrome

Systemic Inflammatory Response Syndrome (SIRS): Or something else? Differential Diagnosis

Diseases that may cause SIRS: Infectious and parasitic diseases (A00-B99). Bleeding, unspecified Ischemia, unspecified – reduced blood supply to an organ. Liver, gallbladder and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87). Pancreatitis (inflammation of the pancreas). Mouth, esophagus (esophagus), stomach, and intestines (K00-K67; K90-K93). Ileus (intestinal obstruction) Injuries, poisoning, and other consequences of external causes … Systemic Inflammatory Response Syndrome (SIRS): Or something else? Differential Diagnosis

Systemic Inflammatory Response Syndrome (SIRS): Complications

The following are the most important diseases or complications that may be contributed to by systemic inflammatory response syndrome (SIRS): Blood, blood-forming organs – Immune system (D50-D90). Coagulation disorders → bleeding/increased clotting (disseminated intravascular coagulation; disseminated intravascular coagulation, DIC syndrome, for short; consumption coagulopathy). Cardiovascular System (I00-I99). Disorders of cardiovascular function Hypotension – too low … Systemic Inflammatory Response Syndrome (SIRS): Complications

Systemic Inflammatory Response Syndrome (SIRS): Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination-including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin, mucous membranes, and sclerae (white part of the eye) [cyanosis (bluish discoloration of the skin/mucous membranes in the absence of oxygen)?; generalized edema (water retention in the tissues)?; petechiae (“flea-like … Systemic Inflammatory Response Syndrome (SIRS): Examination

Systemic Inflammatory Response Syndrome (SIRS): Test and Diagnosis

1st-order laboratory parameters-obligatory laboratory tests. Small blood count [platelets (thrombocytes) ↓] Inflammatory parameter – PCT (procalcitonin)/Guidelines recommend determination of PCT [procalcitonin increases within a few hours (2-3 h) and reaches its maximum after only 24 hours; PCT concentrations: <0.5 ng/mL exclude severe sepsis or septic shock with high probability > 2 ng/mL make severe sepsis … Systemic Inflammatory Response Syndrome (SIRS): Test and Diagnosis

Systemic Inflammatory Response Syndrome (SIRS): Drug Therapy

Therapy recommendations Therapy for SIRS depends on the exact cause or previous illness: Surgical therapy of the underlying disease (focal decontamination) [see “Further Therapy”]. Drug therapy: Antimicrobial therapy Supportive (“adjuvant”) therapy: intensive therapy, circulatory stabilization, volume therapy, insulin therapy, other supportive therapy, if necessary). Airway management/ventilation [see “Further therapy“]. Renal replacement therapy, if necessary [see … Systemic Inflammatory Response Syndrome (SIRS): Drug Therapy

Systemic Inflammatory Response Syndrome (SIRS): Diagnostic Tests

Mandatory medical device diagnostics. Arterial pulse contour analysis (method for monitoring hemodynamics, ie, determination of cardiac output (HMV), in patients requiring intensive care) Invasive blood pressure measurement to determine mean arterial pressure (MAD). Abdominal ultrasonography (ultrasound examination of the abdominal organs) – for basic diagnostics. Electrocardiogram (ECG; recording of the electrical activity of the heart … Systemic Inflammatory Response Syndrome (SIRS): Diagnostic Tests

Systemic Inflammatory Response Syndrome (SIRS): Symptoms, Complaints, Signs

To make the diagnosis of systemic inflammatory response syndrome (SIRS), two of the following criteria must be met: Leading symptoms Respiratory insufficiency (limitation of breathing) with one of the following criteria: Arterial partial pressure of oxygen <70 mmHg during spontaneous breathing. Horowitz index (oxygenation index; paO2/FiO2 < 175 mmHg) – index that provides information about … Systemic Inflammatory Response Syndrome (SIRS): Symptoms, Complaints, Signs

Systemic Inflammatory Response Syndrome (SIRS): Therapy

The therapy of SIRS is complex. In addition to “Drug Therapy,” which is one of the mainstays, “Causal Therapy” and “Supportive Therapy” (for hemodynamic stabilization, see “Drug Therapy”) are of great importance. Causal therapy Surgical therapy if necessary. focal therapy: The basic prerequisite for successful therapy is surgical therapy of the underlying disease or, if … Systemic Inflammatory Response Syndrome (SIRS): Therapy

Systemic Inflammatory Response Syndrome (SIRS): Medical History

Medical history (history of illness) represents an important component in the diagnosis of systemic inflammatory response syndrome (SIRS). Family history What is the current health status of your family members? Social anamnesis Current medical history/systemic history (somatic and psychological complaints). What are the presenting symptoms? Shortness of breath* Pulse racing* Disturbances of consciousness* such as … Systemic Inflammatory Response Syndrome (SIRS): Medical History