Adrenogenital Syndrome

Adrenogenital Syndrome: Drug Therapy

Therapeutic target Symptomatic therapy Therapy recommendations Patients with classic AGS receive superphysiologic glucocorticoid administration for therapy of adrenal androgen overproduction. Furthermore, mineralocorticoid substitution is given (see Therapy below). In men, suppressive therapy also prevents the growth of testicular adrenal residual tumors (TART). Note: In boys, the treating urologist must be informed about the disease to … Adrenogenital Syndrome: Drug Therapy

Adrenogenital Syndrome: Diagnostic Tests

Obligatory medical device diagnostics. Sonography (ultrasonography) of the adrenal glands – to detect hyperplasia (enlargement) of the adrenal cortex. Optional medical device diagnostics – depending on the results of the history, physical examination and obligatory laboratory parameters – for differential diagnostic clarification. Computed tomography (CT; cross-sectional imaging procedure (radiographs taken from different directions with computer-based … Adrenogenital Syndrome: Diagnostic Tests

Adrenogenital Syndrome: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate adrenogenital syndrome (AGS): The expression and severity of symptoms depend on which of the enzymes is defective and the extent to which there is residual activity of the affected enzyme, as well as on the sex of the affected person. Main symptoms of 21-hydroxylase deficiency Consequences of hyperandrogenemia … Adrenogenital Syndrome: Symptoms, Complaints, Signs

Adrenogenital Syndrome: Causes

Pathogenesis (disease development) Adrenogenital syndrome (AGS) results from an enzyme defect. There are several enzymes that may be affected by the defect. The adrenal cortex requires these enzymes for the synthesis (production) of the steroid hormones cortisol and aldosterone. In over 90% of cases, a defect in the enzyme 21-hydoxylase is present in adrenogenital syndrome. … Adrenogenital Syndrome: Causes

Adrenogenital Syndrome: Therapy

Regular checkups Regular medical checkups Nutritional medicine Nutritional counseling based on nutritional analysis Nutritional recommendations according to a mixed diet taking into account gender and age. Observance of the following nutritional recommendations (for prophylaxis of osteoporosis due to glucocorticoid therapy): Calcium-rich (1,000 mg calcium / day) diet: fish, fresh vegetables, dairy and whole grains and … Adrenogenital Syndrome: Therapy

Adrenogenital Syndrome: Medical History

Medical history (history of illness) represents an important component in the diagnosis of adrenogenital syndrome (AGS). Family history Are there frequent metabolic disorders in your family? Social anamnesis Current medical history/systemic history (somatic and psychological complaints). Do you have less appetite? Do you feel exhausted, tired, unable to perform? Are you irritable? Do you suffer … Adrenogenital Syndrome: Medical History

Adrenogenital Syndrome: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90). Idiopathic Addison’s disease with autoantibody formation to 21-hydroxylase. PCO syndrome (synonyms: PCOS; polycystic ovary syndrome; polycystic ovary syndrome; polycystic ovary syndrome; polycystic ovaries; polycystic ovary disease; polycystic ovary syndrome (PCO syndrome); polycystic ovary syndrome; Stein-Leventhal syndrome) – symptom complex characterized by hormonal dysfunction of the ovaries (ovary); this is … Adrenogenital Syndrome: Or something else? Differential Diagnosis

Adrenogenital Syndrome: Complications

The following are the most important diseases or complications that may be contributed to by adrenogenital syndrome (AGS): Endocrine, nutritional, and metabolic diseases (E00-E90). In the female sex: virilization (masculinization). In the male sex: pseudopubertas praecox (form of premature sexual maturity in the juvenile (adolescent) type). Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99). … Adrenogenital Syndrome: Complications

Adrenogenital Syndrome: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin [female gender: male pattern of hair (upper lip beard, hair on chest), oily skin, acne vulgaris; premature pubic hair] Breast development [female sex: lack of breast development] Lack … Adrenogenital Syndrome: Examination

Adrenogenital Syndrome: Test and Diagnosis

1st-order laboratory parameters-obligatory laboratory tests. 21-Hydroxylase deficiency (examination as part of newborn screening). 17-OH-progesterone (determination in the morning during the follicular phase). Androgens DHEA-S [↑] Testosterone [↑] Cortisol [↓] 17α-hydroxyprogesterone [↑* ] In AGS with salt wasting: Sodium [↓] Potassium [↑] Metabolic acidosis (metabolic acidosis). * Nonclassical adrenogenital syndrome (“late-onset” -AGS) and cryptic course can … Adrenogenital Syndrome: Test and Diagnosis