Interaction with other drugs
In the liver, an increased production of the enzyme Cyp 3A4 occurs during the intake of St. John’s wort. This enzyme belongs to the group of so-called cytochrome p450 enzymes. This group of enzymes is used in the body to break down a whole range of substances.
They are particularly important in the activation and breakdown of a whole range of drugs.If the enzyme Cyp 3A4 is now present in larger quantities due to the intake of St. John’s wort, the degradation and activation of all active ingredients, which also need Cyp 3A4 for their metabolism, also changes. This can be life-threatening if the affected drugs are taken due to a serious illness. These include, for example, certain AIDS drugs, antibiotics or immunosuppressants.
There have already been deaths after taking St. John’s wort immunosuppressants have been so severely impaired in their effect that they could no longer be effective sufficiently. Likewise, attention should be paid to possible interactions with cardiac glycosides and anticoagulants. Oral contraceptives (birth control pills) are also partly metabolized by Cyp 3A4 and can therefore be impaired in their effect. You can find more information on this topic at: Pill does not work
ManufacturerTrade names
Manufacturers are given as examples and were selected at random. We have no personal connection with any manufacturer! St. John’s wort Sandoz® 425 mg hard capsules | 60 Tbl.
(N2) | 14.80 € St. John’s wort Sandoz® 425 mg hard capsules | 100 Tbl. (N3) | 23.50 € JOHANNISKRAUT- ratiopharm® 425 | 30 Tbl. (N1) | 7.80 € JOHANNISKRAUT- ratiopharm® 425 | 60 Tbl. (N2) | 14.30 € JOHANNISKRAUT- ratiopharm® 425 | 100 Tbl. (N3) | 23.50 €
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