Interactions
Since antibiotics of the group of macrolides have a similar effect to lincosamine, a combined administration is not advisable, as both drugs can weaken each other in their effect. Oral contraceptives (“pill”) influence the intestinal flora and the circulation of the hormone estrogen. Combined administration with lincosamines can result in a reduced effect of the “pill”. Simultaneous administration of anaesthetics and muscle relaxants can increase the neuromuscular disorders caused by lincosamine, which can lead to muscle weakness, restricted movement and numbness.
Contraindications
In cases of known allergy to the drug group lincosamine and in cases of severe liver failure, Sobelin® should not be given and should rather be switched to other antibiotics. As the lincosamine solution contains benzyl alcohol, it should not be used in infants and newborns.
