Products Sympatholytics are commercially available in the form of tablets, capsules, as injectables, and eye drops, among others. Effects Sympatholytics have sympatholytic properties, meaning that they abolish the effects of the sympathetic nervous system, a portion of the autonomic nervous system. Their effects are usually due to direct antagonism at adrenoceptors. Indirect sympatholytics reduce the … Sympatholytics
Products Dexmedetomidine is commercially available as a concentrate for the preparation of an infusion solution (Dexdor). It was approved in many countries in 2012. Structure and properties Dexmedetomidine (C13H16N2, Mr = 200.3 g/mol) is an imidazole derivative and the -enantiomer of medetomidine. It is structurally closely related to detomidine and is present in drugs as … Dexmedetomidine
Products Reserpine was commercially available in many countries in the form of dragées as a fixed combination with dihydroergocristin and clopamide (Brinerdin, off label). Structure and properties Reserpine (C33H40N2O9, Mr = 609 g/mol) exists as a crystalline powder or as small, white to faint yellow crystals that slowly darken under the influence of light. The … Reserpine
Products Sotalol is commercially available in tablet form (generic). It has been approved in many countries since 1980. The original Sotalex is out of commerce. Structure and properties Sotalol (C12H20N2O3S, Mr = 272.4 g/mol) is present in drugs as sotalol hydrochloride, a racemate and white powder that is readily soluble in water. Sotalol is a … Sotalol
Products No finished drug products containing tolazoline are on the market in many countries. Structure and properties Tolazoline (C10H12N2, Mr = 160.2 g/mol) Effects Tolazoline (ATC C04AB02, ATC M02AX02) is α-sympatholytic and vasodilatory.
Products Eprosartan is commercially available in the form of film-coated tablets (Teveten, generics). It has been approved in many countries since 1999 and is also used in fixed combination with hydrochlorothiazide (Teveten plus, generic). Structure and properties Eprosartan (C23H24N2O4S, Mr = 424.5 g/mol) is present in drugs as eprosartan mesilate, a white crystalline powder that … Eprosartan
Products Urapidil is commercially available as a solution for injection (Ebrantil). It has been approved in many countries since 1983. Structure and properties Urapidil (C20H29N5O3, Mr = 387.5 g/mol) is a derivative of uracil and piperazine. It is present in drugs as urapidil hydrochloride. Effects Urapidil (ATC C02CA06) has antihypertensive and sympatholytic properties. It lowers … Urapidil
Medicinal drug Rauwolfiae radix – Rauvolfia root. Ingredients Indole alkaloids (Rauwolfia alkaloids): reserpine, ajmaline, ajmalicine. Effects Antihypertensive by depleting adrenergic, serotoninergic, and dopaminergic nerve endings. Sympatholytic Reassuring Antiarrhythmic due to sodium channel blockade (ajmaline) Indications Drug: mild essential hypertension. Reserpine as pure substance: hypertension. It is rarely used today (UAW). Ajmaline as a pure substance: … Rauvolfia
Symptoms Hypoglycemia is an abnormally low blood glucose level. The organism first tries to counteract by activating the sympathetic nervous system, because this increases the level. Central symptoms occur because the brain is no longer supplied with sufficient glucose (neuroglycopenia). The brain can hardly store glucose and is dependent on a continuous supply. Possible symptoms … Hypoglycemia (Diabetes Treatment)
Products Oxprenolol is no longer available in many countries. Trasicor, slow-trasitensine (+ chlortalidone), and slow-trasicor are off label. Structure and properties Oxprenolol (C15H23NO3, Mr = 265.3 g/mol) is present in drugs as oxprenolol hydrochloride, a racemate and a white crystalline powder that is very soluble in water. Effects Oxprenolol (ATC C07AA02) has antihypertensive and antiarrhythmic … Oxprenolol
Products Terazosin is commercially available in tablet form (Hytrin BPH) and has been approved in many countries since 1994. It is no longer registered for the treatment of high blood pressure in many countries (formerly Hytrin), but the indication still exists in other countries. Structure and properties Terazosin (C19H25N5O4, Mr = 387.4 g/mol) is a … Terazosin
Products Alpha blockers are available in many countries in the form of tablets, sustained-release tablets, capsules, and sustained-release capsules. The most commonly prescribed today is tamsulosin (Pradif T, generic). Alpha blocker is short for alpha1-adrenoreceptor antagonist. Structure and properties The first alpha blockers-alfuzosin, doxazosin, and terazosin-were developed as derivatives of quinazoline: Effects Alpha blockers (ATC … Alpha Blocker
