Synonyms in a broader sense
- Systemic lupus erythematosus
- SLE
- Lupus erythematodes disseminatus
Therapy
The therapy depends on the type of disease. If, for example, lupus is caused by medication, these drugs are discontinued if possible. The focus is on cortisone and immunosuppressants, i.e. substances that suppress the immune system.
Cortisone is primarily intended to inhibit inflammation in the affected organs, while immunosuppressants are intended to suppress the body’s own defence system. The latter can be explained by the fact that in lupus our immune system is directed against the body’s own cells. This undesirable effect must be curbed.
In the case of cutaneous lupus (i.e. lupus which is restricted to the skin) retinoids (vitamin A derivatives), creams with a high sun protection factor and cortisone ointments are used. If the lupus is one of the most severe types, i.e. systemic lupus erythematosus (SLE), the therapy is as follows: In any case, it is very important to maintain a good blood pressure in order to preserve the function of the kidney, which is already endangered by the disease itself. In cases that are less pronounced and where no organs are affected, painkillers such as ASS 100 or ibuprofen, plus hydrochloroquine are given to relieve joint pain.
Cortisone is only administered in inflammatory phases. If there is a severe case with impairment of (vital) organs, the therapy is different. Here, high doses of cortisone are given and the body’s own defense system is suppressed by immunosuppressive agents.
Cortisone and immunosuppressants suppress the body’s defense system. This ensures that the immune complexes which want to fight the deposited DNA do not form in the first place. The body’s defence system is therefore so poor that the trigger of the disease cannot be fought at all.
However, strong suppression (suppression) of the immune system must be handled with caution, as there is a high risk of infection for the patient. Even the slightest cold can be dangerous for these patients. The now suppressed and less working immune system can also fight viruses, bacteria and other pathogens much more poorly.