Heartburn (Pyrosis): Causes
Pathogenesis (development of disease) The following pathophysiologic mechanisms may contribute to heartburn (pyrosis): Aggressive gastric juice Impaired self-cleaning powers of the esophagus (food pipe). Insufficiency (weakness) lower esophageal sphincter (lower sphincter of the esophagus) (about 20% of cases are due to anatomical and functional changes). Delayed gastric emptying Change in the anatomical location of the … Heartburn (Pyrosis): Causes