There are moderate interactions between silymarin and drugs that are metabolized (metabolized) in the liver via cytochromes P450 2C9. Concomitant use of silymarin and these drugs may slow their breakdown and increase their effects and side effects. Furthermore, there are interactions between milk thistle and glucuronidated drugs. In this case, the effect of the drugs … Silymarin (Milk Thistle Fruit Extract): Interactions
Traditionally and to this day, milk thistle is used as a medicinal plant and is not suitable as a food. As a tea, dry extract, or powder, it is used for diseases of the liver, gallbladder, and spleen. In Europe, silymarin is available in both medicinal products and dietary supplements in the form of tea, … Silymarin (Milk Thistle Fruit Extract): Food Products
No adverse effects have been reported in clinical intervention studies conducted to date. In animal studies, oral intake of a maximum of 2,500 to 5,000 mg/kg silymarin has been shown to be nontoxic and symptom-free. Caution should be exercised in cases of hypersensitivity to the active ingredient and other plants of the genus Asteraceae (or … Silymarin (Milk Thistle Fruit Extract): Safety Evaluation
The following are active substances (micronutrients) that also perform important tasks in the body: In addition to macronutrients (carbohydrates, proteins, fats) and the well-known vital substances – vitamins, minerals, trace elements, essential fatty acids, essential amino acids, and bioactive substances – there are numerous compounds in foods that also perform important vitamin-like functions in the … Other Vital Substances
In the root of the sleeping berry, approximately 1.33% of withanolides and 0.13%-0.31% of alkaloids are present. In comparison, in the leaves, the concentrations of withanolides and alkaloids are increased by 1.8 times and 2.6 times, respectively.The extracts used in dietary supplements are usually standardized to 1.5% withanolides . The German Federal Institute for Risk … Winter Cherry (Withania Somnifera): Supply Situation
Silymarin is a fruit extract and comes from milk thistle (Silybum marianum). This medicinal plant belongs to the composite family (Asteraceae), subfamily Carduoideae. With a stem height of 20 cm to 150 cm, the annual to biennial herb is easily recognizable by its white-green marbled leaves and purple flower. Milk thistle grows preferentially on dry, … Silymarin (Milk Thistle Fruit Extract): Definition, Metabolism, Bioavailability
Traditionally, silymarin has been used as a tea or dry extract to treat diseases of the liver, gallbladder, and spleen. It is now one of the best-studied phytochemicals.Based on clinical data, silymarin is used supportively for the following conditions: Alcohol-related liver disease Cirrhosis of the liver Acute and chronic hepatitis Liver disease induced by drugs, … Silymarin (Milk Thistle Fruit Extract): Functions
Rhodiola rosea is increasingly used in dietary supplements because of its adaptogenic effects. No data on the supply situation are available to date.
In the European Union, Rhodiola rosea is mostly used as a root extract in dietary supplements.
Sleepberry (Withania somnifera) is a commonly used medicinal plant in India and belongs to the nightshade family (Solanaceae). The plant, which has been used for 3,000 years, is also known as ashwagandha, winter cherry or Indian ginseng. The herbaceous plant prefers dry, stony soil with sun to partial shade and can reach a height of … Winter Cherry (Withania Somnifera): Definition
In Ayurvedic medicine, the sleep berry is very often used due to its diverse effectiveness. Traditionally, mainly the leaves and roots of the medicinal plant are used with the aim of promoting calmness and clarity of mind, as well as rebalancing body and mind. According to this, the sleeping berry is said to have memory-enhancing, … Winter Cherry (Withania Somnifera): Functions
According to WHO (World Health Organization) data, ingestion of sleepberry may increase the effects of barbiturates and reduce the effects of diazepam and clonazepam.