Products Benralizumab was approved as a solution for injection in the United States in 2017 and in the EU and many countries in 2018 (Fasenra). Structure and properties Benralizumab is a humanized and afucosylated IgG1κ antibody with a molecular mass of 150 kDa. It is produced by biotechnological methods. Omission of the fucose in the … Benralizumab
Symptoms A dust mite allergy manifests itself in allergic symptoms. These include: Perennial allergic rhinitis: sneezing, runny nose, in the later course of the disease rather a chronically stuffy nose. Allergic conjunctivitis: itchy, watery, swollen and red eyes. Sinusitis with headache and facial pain Lower respiratory tract: cough, bronchial asthma. Itching, rash, eczema, exacerbation of … House Dust Mite Allergy
1. symptom treatment Beta2-sympathomimetics are derived from epinephrine. They selectively stimulate the adrenergic β2-receptors of bronchial muscles and thus have a bronchospasmolytic effect. For rapid symptom relief, fast-acting agents are usually administered by inhalation, for example, with a metered-dose inhaler or a powder inhaler. They should be used only when needed. An increase in administration … Antiasthmatics
Products and ingredients Inhalation solution B is not commercially available as a finished drug in many countries and must be prescribed by a physician as an extemporaneous prescription and prepared in a pharmacy. In practice, different manufacturing prescriptions are used with the pure substances or the solutions. Dospir and Ipramol have a similar composition, but … Inhalation Solution B
Products Omalizumab is commercially available as a powder and solvent for solution for injection (Xolair). It has been approved in many countries since 2006. Structure and properties Omalizumab is a recombinant, humanized monoclonal antibody with a molecular weight of approximately 149 kDa. Effects Omalizumab (ATC R03DX05) has antiallergic and antiasthmatic properties. The effects are based … Omalizumab
Products Reslizumab was approved in the United States and EU in 2016 and in many countries in 2017 as a concentrate for the preparation of an infusion solution (Cinqaero). Structure and properties Reslizumab is a humanized IgG4/κ monoclonal antibody produced by biotechnological methods. The molecular mass is approximately 147 kDa. Effects Reslizumab (ATC R03DX08) binds … Reslizumab
Symptoms Asthma causes narrowing and obstruction of the airways, which manifests itself in symptoms such as coughing, shortness of breath, a feeling of tightness, sounds when breathing out, and wheezing (whistling, rattling, rattling). The bronchi become constricted and a thick mucus forms. The disorders occur episodically and frequently at night and early in the morning, … Asthma
Products Zafirlukast was commercially available in the form of film-coated tablets (Accolate, off label). It was approved in many countries in 1998. It was discontinued from distribution in 2019. Montelukast is a suitable substitute. Structure and properties Zafirlukast (C31H33N3O6S, Mr = 575.7 g/mol) exists as a fine, white to pale yellow, amorphous powder that is … Zafirlukast
Products LABA is an acronym for , which means long-acting beta agonists (sympathomimetics). LABAs are mainly marketed as inhaled preparations (powders, solutions) administered with an inhaler such as a metered-dose inhaler, diskus, respimat, breezhaler, or ellipta. Some may also be given perorally. Salmeterol and formoterol were the first agents from this group to be approved … LABA
Application Compose chamber Spray appropriate number of doses into chamber with metered dose inhaler Exhale Taking a deep breath, holding the breath Clean regularly according to the package insert Selected products Able Spacer Aerochamber: GlaxoSmithKline (Ventolin, Axotide) Babyhaler by GlaxoSmithKline Fisonair (Sanofi-Aventis) Nebuhaler (Bricanyl and Pulmicort, out of trade). Pari Vortex Volumatic (GlaxoSmithKline, out of … Upstream Chambers
Products Leukotriene antagonists are commercially available as film-coated tablets, granules, and chewable tablets. Structure and properties The active ingredients do not have a uniform chemical structure. Effects The leukotriene antagonists (ATC R03DC) have antiasthmatic, anti-inflammatory, bronchodilator, and antiallergic properties. They bind to the CysLT1 receptor, thereby inhibiting the effects of the cysteinyl leukotrienes LTC4, LTD4, … Leukotriene Antagonists
Effects Leukotriene synthesis inhibitors are antiallergic and anti-inflammatory. Mechanism of action Inhibition of the synthesis of leukotrienes from arachidonic acid by inhibition of 5-lipoxygenase. Indications For prevention and long-term therapy of asthma in adults and children over 12 years of age. Active ingredients Zileuton (USA: Zyflo) – not commercially available in many countries.
