Products Phentolamine was commercially available as a solution for injection in many countries (Regitin, out of trade). Structure and properties Phentolamine (C17H19N3O, Mr = 281.4 g/mol) is present in drugs as phentolamine mesilate, a white, crystalline, slightly hygroscopic powder that is readily soluble in water. Effects Phentolamine (ATC C04AB01) is a competitive nonselective alpha1– and … Phentolamine
Products Phenylephrine is commercially available in the form of nasal drops, as a nasal spray, nasal gel, eye drops, oral powder, as an injectable, and in capsules as a mono- or combination preparation (e.g., Neo-Citran, Triofan Rhinitis Capsules, Vibrocil). It has been approved in many countries since 1968. Rhinopront is off the market. See also … Phenylephrine
Products Terazosin is commercially available in tablet form (Hytrin BPH) and has been approved in many countries since 1994. It is no longer registered for the treatment of high blood pressure in many countries (formerly Hytrin), but the indication still exists in other countries. Structure and properties Terazosin (C19H25N5O4, Mr = 387.4 g/mol) is a … Terazosin
Products Phosphodiesterase-5 inhibitors are commercially available in the form of film-coated tablets and meltable tablets. Sildenafil (Viagra) was the first active ingredient from this group to be approved in the United States, the EU, and many countries in 1998. Generics are also available today. Sildenafil was originally to be developed by Pfizer for the treatment … Phosphodiesterase-5 Inhibitors
Products Alpha blockers are available in many countries in the form of tablets, sustained-release tablets, capsules, and sustained-release capsules. The most commonly prescribed today is tamsulosin (Pradif T, generic). Alpha blocker is short for alpha1-adrenoreceptor antagonist. Structure and properties The first alpha blockers-alfuzosin, doxazosin, and terazosin-were developed as derivatives of quinazoline: Effects Alpha blockers (ATC … Alpha Blocker
Products Imidapril is registered as a powder for oral solution (Prilium). It has been approved in many countries since 2004. Imidapril has also been used in humans, but no human medicines are currently registered in many countries (Tanatril). Structure and properties Imidapril (C20H27N3O6, Mr = 405.4 g/mol) is a prodrug and is biotransformed by ester … Imidapril
Products Aronia berries, aronia juice, aronia tea, capsules and other products are available in pharmacies and drugstores, among others. Aronia is counted among the so-called superfoods. Stem plant The chokeberry bushes (black berries, black chokeberry) and (red berries, felty chokeberry) from the rose family originally come from North America. They also reached Europe in the … Chokeberry
The feeling of constant fatigue is an everyday burden for many people. In many cases, however, no exact cause can be found despite extensive diagnostic work. Daytime fatigue often tends to become chronic and can negatively affect life in all areas. What is constant fatigue? Sporadic fatigue in itself, therefore, does not yet have disease … Constant Fatigue: Causes, Treatment & Help
Products The fixed combination of the neprilysin inhibitor sacubitril with valsartan was approved in the United States, the EU, and many countries in 2015 in the form of film-coated tablets (Entresto). The combination is also referred to as LCZ696. Structure and properties Sacubitril (C24H29NO5, Mr = 411.5 g/mol) is an ester prodrug that is hydrolyzed … Sacubitril
Products Avanafil is commercially available in tablet form (Spedra, some countries: Stendra). It was approved in the US in April 2012, in the EU in 2013, and in many countries in 2016. Structure and properties Avanafil (C23H26ClN7O3, Mr = 483.95 g/mol) is a pyrimidine derivative. It exists as a white crystalline powder that is practically … Avanafil
Products Bunazosin is commercially available in the form of sustained-release tablets (Andante). The drug is not registered in many countries. Structure and properties Bunazosin (C19H27N5O3, Mr = 373.4 g/mol) is present in drugs as bunazosin hydrochloride. It is a quinazoline derivative. Effects Bunazosin (ATC C02CA) is antihypertensive. Its effects are due to selective and competitive … Bunazosin
Guanethidine is a drug used in the therapy of hypertension (high blood pressure) and in local anesthesia to numb certain nerves. The main pharmaceutical producer of guanethidine is the company Alcon, which markets the active ingredient under the name Thilodigon. Thus, guanethidine represents both an antihypertensive and an antisympathotonic agent. What is guanethidine? Guanethidine is … Guanethidine: Effects, Uses & Risks