Products Sedatives are commercially available in the form of tablets, melting tablets, drops, as injectables and tinctures, among others. Structure and properties Sedatives do not have a uniform chemical structure. Effects The active ingredients have sedative properties. Some are additionally antianxiety, sleep-inducing, antipsychotic, antidepressant, and anticonvulsant. The effects are due to promotion of inhibitory mechanisms … Sedative
Products Olanzapine is commercially available as film-coated tablets, meltable tablets, and powder for solution for injection (Zyprexa, generics). It has been approved in the U.S. and EU since 1996 and in many countries since 1997. Generic versions entered the market in 2012. Structure and properties Olanzapine (C17H20N4S, Mr = 312.4 g/mol) belongs to the thienobenzodiazepine … Olanzapine
Products Lithium is commercially available in the form of tablets and sustained-release tablets (e.g., Quilonorm, Priadel, Lithiofor). Structure and properties The lithium ion (Li+) is a monovalent cation found in pharmaceuticals in the form of various salts. These include lithium citrate, lithium sulfate, lithium carbonate, and lithium acetate. For example, lithium carbonate (Li2CO3, Mr = … Lithium: Drug Effects, Side Effects, Dosage and Uses
Products Clotiapine is commercially available in tablet form (Entumin). It has been approved in many countries since 1967. Structure and properties Clotiapine (C18H18ClN3S, Mr = 343.87 g/mol) is a dibenzothiazepine. The structurally closely related neuroleptic quetiapine (Seroquel) also belongs to this group of drugs. Effects Clotiapine (ATC N05AH06) has adrenolytic, antidopaminergic, anticholinergic, antihistamine, sedative, psychomotor … Clotiapine
Products Clozapine is commercially available in tablet form (Leponex, generic). It has been approved in many countries since 1972. It is also known as Clozaril in some countries. Clozapine was developed at Wander and Sandoz. Structure and properties Clozapine (C18H19ClN4, Mr = 326.8 g/mol) exists as a yellow crystalline powder that is practically insoluble in … Clozapine
Products Penfluridol is no longer available as a drug in many countries. Semap tablets are out of commerce. Structure and properties Penfluridol (C28H27ClF5NO, Mr = 523.96 g/mol) is a diphenylbutylpiperidine. Effects Penfluridol (ATC N05AG03) is potent antidopaminergic, antiemetic, and potent antipsychotic against hallucinations and delusions. It has minimal activity at the 5-HT2 receptor (antiserotonergic) and … Penfluridol
Products In many countries, there are currently no medicines approved that contain only cannabidiol. However, the active ingredient is a component of the cannabis oral spray Sativex, which is registered as a drug for MS treatment in many countries and also contains THC. The oral solution Epidiolex or Epidyolex was approved as a drug in … Cannabidiol
Products Hemp with a high content of cannabidiol and a low total content of tetrahydrocannabinol (less than 1%) can be legally sold in many countries since 2016 and is available from specialized suppliers and web stores. Cannabidiol hemp is approved as a tobacco substitute product and not yet as a medicine. Neither cannabidiol nor cannabidiol … Cannabidiol Hemp
Effects Diphenylbutylpiperidines are antidopaminergic, antipsychotic, and antiemetic. Mechanism of action Dopamine antagonists Indications Clinical pictures of the schizophrenic type. Structure and properties Derivatives of diphenylbutylpiperidine. Active ingredients Penfluridol (Semap, off label). Fluspirilen (IMPA, D) Pimozide (out of commerce)
Products Droperidol is commercially available as a solution for injection (Droperidol Sintetica). It has been approved in many countries since 2006. Structure and properties Droperidol (C22H22FN3O2, Mr = 379.4 g/mol) structurally belongs to the butyrphenones and exists as a white powder that is practically insoluble in water. It is a benzimidazolinone derivative. Effects Droperidol (ATC … Droperidol
Products There are no drugs containing bromperidol on the market in many countries. Structure and properties Bromperidol (C21H23BrFNO2, Mr = 420.3 g/mol) exists as a white powder that is practically insoluble in water. It is identical to haloperidol but is brominated instead of chlorinated. Bromperidol is a butyrphenone derivative. Bromperidol decanoate (depot injection) is also … Bromperidol
Sulpiride is an active ingredient from the benzamide group. It belongs to the so-called atypical neuroleptics, but also has an antidepressant effect. Sulpiride mainly stimulates certain dopamine receptors in the brain (D2 and D3 receptors). In low doses, sulpiride has a stimulating and mood-lifting effect. In higher doses (from about 300-600mg/day) it also has an … Sulpiride
