Products Encorafenib was approved in capsule form in the United States and EU in 2018 and in many countries in 2019 (Braftovi). Structure and properties Encorafenib (C22H27ClFN7O4S, Mr = 540.0 g/mol) exists as a white powder that is somewhat soluble in water only at low pH. Effects Encorafenib (ATC L01XE46) has antitumor and antiproliferative properties. … Encorafenib
Products Cetuximab is commercially available as an infusion solution (Erbitux). It has been approved in many countries since 2003. Structure and properties Cetuximab is a recombinant chimeric (human/mouse) IgG1 monoclonal antibody. It is produced by biotechnological methods. Effects Cetuximab (ATC L01XC06) has antitumor and antiangiogenic properties. It is a specific antibody against the epidermal growth … Cetuximab
Products Pembrolizumab was approved as an infusion product in the United States in 2014 and in the EU and many countries in 2015 (Keytruda). Structure and properties Pembrolizumab is a humanized monoclonal antibody. It is an IgG4-κ immunoglobulin with a molecular weight of approximately 149 kDa. Effects Pembrolizumab (ATC L01XC18) has antitumor and immunomodulatory properties. … Pembrolizumab
Products Pemetrexed is commercially available as an infusion drug (Alimta, generic). It has been approved in many countries since 2005. Structure and properties Pemetrexed (C20H21N5O6, Mr = 427.4 g/mol) is a folic acid analog. It is present in drugs hydrated and as a disodium salt, in the original preparation as pemetrexed disodium heptahydrate, a white … Pemetrexed
Products COX-2 inhibitors (coxibe) are commercially available in the form of film-coated tablets and capsules. The first representatives from this group to be approved in many countries were celecoxib (Celebrex, USA: 1998) and rofecoxib (Vioxx, off label) in 1999. At that time, they rapidly developed into blockbuster drugs. However, due to adverse effects, several drugs … COX-2 Inhibitor
Products Cabozantinib is commercially available in the form of film-coated tablets (Cabometyx). It was approved in the United States in 2012, in the EU in 2013, and in many countries in 2017. In some countries, Cometriq capsules are additionally on the market for the treatment of medullary thyroid carcinoma. This article relates to renal cell … Cabozantinib
Products Pazopanib is commercially available in the form of film-coated tablets (Votrient). It was approved in the EU and many countries in 2010. Structure and properties Pazopanib (C21H23N7O2S, Mr = 437.52 g/mol) exists in drugs as pazopanib hydrochloride, a white to yellowish solid that is sparingly soluble in water at pH 1 and practically insoluble … Pazopanib
Products Peginterferon beta-1a is commercially available as a solution for injection in a prefilled syringe (Plegridy). It was approved in many countries in 2015. Structure and properties Peginterferon beta-1a is a covalent conjugate of interferon beta-1a (Rebif) and methoxypolyethylene glycol with methylpropionaldehyde as a linker. Effects Peginterferon beta-1a (ATC L03AB13) has antiviral, antiproliferative, antitumor, and … Peginterferon Beta-1A
Products Sonidegib was approved in many countries in 2015 in capsule form (Odomzo). Structure and properties Sonidegib (C26H26F3N3O3, Mr = 485.5 g/mol) is present in the drug as sonidegib diphosphate. It is a biphenyl carboxamide. Effects Sonidegib (ATC L01XX48) has antitumor and antiproliferative properties. The effects are due to inhibition of the Hedgehog signaling pathway … Sonidegib
Products Sorafenib is commercially available in the form of film-coated tablets (Nexavar). It has been approved in many countries since 2006. Structure and properties Sorafenib (C21H16ClF3N4O3, Mr = 464.8 g/mol) is present in drugs as sorafenibtosilate, a white to yellowish or brownish powder that is practically insoluble in water. Effects Sorafenib (ATC L01XE05) has antiproliferative, … Sorafenib
Products Blinatumomab is commercially available as an infusion product (Blincyto). It has been approved in the United States since 2014, in the EU since 2015, and in many countries since 2016. Structure and properties Blinatumomab is an antibody construct (fusion protein) of 504 amino acids with a molecular weight of approximately 54 kDa. It consists … Blinatumomab
Products MSM is commercially available in the form of tablets, capsules and powder, among others, as a food supplement without indications. It is also applied externally, for example, as a cream and balm. Medicines containing MSM have not yet been approved. Structure and properties MSM (C2H6O2S, Mr = 94.1 g/mol) is a low molecular weight … MSM (Methylsulfonylmethane)
