Products Olanzapine is commercially available as film-coated tablets, meltable tablets, and powder for solution for injection (Zyprexa, generics). It has been approved in the U.S. and EU since 1996 and in many countries since 1997. Generic versions entered the market in 2012. Structure and properties Olanzapine (C17H20N4S, Mr = 312.4 g/mol) belongs to the thienobenzodiazepine … Olanzapine
Products Clozapine is commercially available in tablet form (Leponex, generic). It has been approved in many countries since 1972. It is also known as Clozaril in some countries. Clozapine was developed at Wander and Sandoz. Structure and properties Clozapine (C18H19ClN4, Mr = 326.8 g/mol) exists as a yellow crystalline powder that is practically insoluble in … Clozapine
Introduction The clinical picture of schizophrenia should not be underestimated. Once the diagnosis has been made, it should be treated immediately, because the earlier schizophrenia is treated, the better the effect on the further course of treatment. In the following, the drug therapy for schizophrenia will be discussed in particular. For general information we recommend … Schizophrenia – These drugs are used!
What are antidepressants? Antidepressants are substances used to treat symptoms of depression. In the context of a schizophrenic disorder, this makes sense because many patients develop depression as a concomitant disease. Antidepressants unfold their effect by increasing the concentration of messenger substances in the brain, which are important for mood and drive. These are mainly … What are antidepressants? | Schizophrenia – These drugs are used!
What do I have to consider when stopping the medication? Schizophrenia is a long-term condition that often leads to relapses. Thus, schizophrenia accompanies some patients throughout their lives. Medication must therefore be taken over a long period of time, even after the symptoms have subsided, to prevent relapses. If they are discontinued too early or … What do I have to consider when stopping the medication? | Schizophrenia – These drugs are used!
How fast do the drugs work? The onset of action depends on the type of medication. Benzodiazepines such as Valium® as a sedative usually act very quickly. If they are administered into the vein, the effect is even immediate. Antipsychotics and antidepressants, on the other hand, need a few days to weeks before they take … How fast do the drugs work? | Schizophrenia – These drugs are used!
Products Sertindole is commercially available in the form of film-coated tablets (Serdolect). It has been approved in many countries since 1997. Structure and properties Sertindole (C24H26ClFN4O, Mr = 440.9 g/mol) was developed as the first neuroleptic with a phenylindole structure. Effects Sertindole (ATC N05AE03) has antipsychotic properties. The effects are due to antagonism at dopamine … Sertindol
Products Brexpiprazole was approved in the United States in 2015 and in the EU and many countries in 2018 in film-coated tablet form (Rexulti). Structure and properties Brexpiprazole (C25H27N3O2S, Mr = 433.6 g/mol) is structurally closely related to aripiprazole (Abilify, generics). Effects Brexpiprazole (ATC N05AX16) has antipsychotic properties. The effects are due to partial agonism … Brexpiprazole
Products Aripiprazole is commercially available in tablet, meltable tablet, syrup, solution for injection, and sustained-release injection suspension forms (Abilify, Abilify Maintena, generics). It has been approved in many countries since 2004 and in the United States since 2002. Generics entered the market in 2015. Also used is the prodrug aripiprazollauroxil (Aristada). Structure and properties Aripiprazole … Aripiprazole
Products Aripiprazollauroxil was newly approved in the United States in 2015 as a suspension for injection (Aristada). It has not yet been registered in many countries. Structure and properties Aripiprazollauroxil (C36H51Cl2N3O4, Mr = 660.7 g/mol) is the ester of -hydroxymethyl aripiprazole and lauric acid. Aripiprazollauroxil is a prodrug of aripiprazole (Abilify, generic). Unlike oral aripiprazole, … Aripiprazollauroxil
Definition Neuroleptics (synonym: antipsychotics) is a group of drugs that are used to treat a number of different mental illnesses. These include, for example, schizophrenia or delusional states. In addition to these diseases, some neuroleptics are also used in the presence of chronic pain as well as in the field of anesthesia. The group of … Neuroleptics
Stopping the neuroleptics There can be different reasons why a neuroleptic must be discontinued. However, the brain adapts to the changes caused by the use of neuroleptics, which is why abrupt discontinuation of a neuroleptic is not recommended and can be accompanied by severe side effects. It is very difficult to predict which side effects … Stopping the neuroleptics | Neuroleptics
