bezafibrate

Bezafibrate: Effects, Applications, Side Effects

How bezafibrate works Bezafibrate and other fibrates activate certain docking sites for endogenous messenger substances in liver cells, the so-called peroxisome proliferator-activated receptors (PPAR). These receptors regulate the activity of genes involved in fat and carbohydrate metabolism. Overall, the intake of bezafibrate primarily lowers triglycerides. At the same time, the LDL value is slightly lowered … Bezafibrate: Effects, Applications, Side Effects

Fibrates: Effects, Uses & Risks

Fibrates are carboxylic acids and belong to the organic compounds. Various representatives such as clofibrate, gemfibrozil and etofibrate are known on the market. Fibrates bind to specific receptors in cell organelles, causing a reduction in blood lipid levels. They are therefore used to treat lipid disorders such as high cholesterol or triglyceride levels. Fibrates should … Fibrates: Effects, Uses & Risks

Lipid-Lowering Agents

Products Lipid-lowering agents are mainly sold as tablets and capsules as monopreparations and combination preparations. Some other dosage forms exist, such as granules and injectables. Statins have established themselves as the most important group at present. Structure and properties The chemical structure of lipid-lowering agents is inconsistent. However, within the class, groups with comparable structures … Lipid-Lowering Agents

Fibrate

Effects Fibrates (ATC C10AB) have lipid-lowering properties. They primarily lower elevated blood triglyceride levels and have a moderate effect on LDL cholesterol and slightly increase HDL. The effects are due to activation of nuclear receptors PPAR (mainly PPARα). Indications Blood lipid disorders, especially hypertriglyceridemia. Agents Bezafibrate (Cedur retard) Fenofibrate (Lipanthyl) Fenofibric acid (Trilipix) Gemfibrozil (Gevilon) … Fibrate

Fluvastatin

Products Fluvastatin is commercially available in the form of capsules and sustained-release generic tablets (generics). It has been approved in many countries since 1993. Sales of the original Lescol were discontinued by Novartis in 2018. Structure and properties Fluvastatin (C24H26FNO4, Mr = 411.5 g/mol) is present in drugs as fluvastatin sodium, a white or pale … Fluvastatin

Bezafibrate

Products Bezafibrate is commercially available in the form of sustained-release tablets (Cedur retard). It has been approved in many countries since 1979. Structure and properties Bezafibrate (C19H20ClNO4, Mr = 361.8 g/mol) lies as a white crystalline powder that is practically insoluble in water. Effects Bezafibrate (ATC C10AB02) primarily lowers elevated blood triglyceride levels. It has … Bezafibrate

Clofibrate: Effects, Uses & Risks

Clofibrate is a derivative of clofibric acid and, along with statins and nicotinic acids, belongs to the group of active substances known as lipid-lowering agents. Clofibrate primarily lowers elevated plasma levels of triglycerides; the cholesterol-lowering effect is less pronounced. What is clofibrate? Clofibrate (chemical name: ethyl 2-(4-chlorophenoxy)-2-methylpropanoate) belongs to the group of fibrates, a group … Clofibrate: Effects, Uses & Risks

Bezafibrate: Effects, Uses & Risks

Bezafibrate belongs to the group of fibrates. Bezafibrate is a lipid-lowering agent and, along with statins and nicotinic acid, is an important therapeutic option for the treatment of elevated triglycerides in particular, but also elevated cholesterol in some cases. What is bezafibrate? Bezafibrate (chemical name: 2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropionic acid), like clofibrate or fenofibrate, is a derivative of … Bezafibrate: Effects, Uses & Risks