Products Nifedipine is commercially available in the form of sustained-release tablets (generics). It was first approved in the mid-1970s. Sales of the original Adalat were discontinued in many countries in 2019. Structure and properties Nifedipine (C17H18N2O6, Mr = 346.3 g/mol) is a dihydropyridine. It exists as a yellow crystalline powder that is practically insoluble in … Nifedipine: Drug Effects, Side Effects, Dosage and Uses
Symptoms Symptoms of altitude sickness are nonspecific and usually appear 6-10 hours after ascent. However, they can also occur after as little as one hour: Headache Dizziness Sleep disorders Loss of appetite Nausea and vomiting Fatigue and tiredness Rapid heartbeat Accelerated breathing, shortness of breath Severe symptoms: Cough Shortness of breath even at rest Tightness … Altitude Sickness
Causes and classification 1. primary, idiopathic headache without underlying disease: Tension headache Migraine Cluster headache Mixed and other, rarer primary forms. 2. secondary headache: the causes of secondary headache as a result of a disease, a particular condition or substances are numerous: head or cervical trauma: Posttraumatic headache Cervical spine acceleration trauma Vascular disorders of … Headache
Products Isradipine is commercially available in capsule form (Lomir SRO). It has been approved in many countries since 1991. Structure and properties Isradipine (C19H21N3O5, Mr = 371.4 g/mol) is a racemate. It exists as a yellow crystalline powder that is practically insoluble in water. Effects Isradipine (ATC C08CA03) has antihypertensive properties. Its effects are due … Isradipine
Products Lercanidipine is commercially available in the form of film-coated tablets (Zanidip, Zanipress + enalapril). It has been approved in many countries since 2004. Generic versions were registered in 2014. Structure and properties Lercanidipine (C36H41N3O6, Mr = 611.7 g/mol) is a dihydropyridine. It is present in drugs as lercanidipine hydrochloride. The -enantiomer is primarily active. … Lercanidipine
Active ingredients ACE inhibitors Sartans Renin inhibitors Calcium channel blockers Beta blockers Diuretics Alpha blockers Centrally acting antihypertensives: Clonidine Methyldopa Moxonidine Reserpine Organic nitrates Herbal antihypertensives: Garlic Hawthorn
Products Methoxyflurane has been approved in many countries since 2018 as a liquid to produce a vapor for inhalation (Penthrox, inhaler). In Australia, the drug has been used since the early 1970s. The active ingredient was originally launched in the 1960s as an anesthetic, but is no longer used as such. Structure and properties Methoxyflurane … Methoxyflurane
Indications Inhibition of labor during pregnancy to prevent preterm delivery Active ingredients Minerals: Magnesium (e.g. magnesium diasporal). Calcium channel blockers: Nifedipine (Adalat, generic, off-label). Progestins: Progesterone (Utrogestan) Probiotics: Lactobacilli (vaginal suppositories to prevent infections). Oxytocin antagonists: Atosiban (Tractocile). Sympathomimetics: Hexoprenaline (Gynipral) Fenoterol (no indication in many countries). Salbutamol (Ventolin, no indication in many countries). Other … Labor Inhibitors
Products Hydrochlorothiazide is commercially available in numerous antihypertensive agents in combination with ACE inhibitors, sartans, renin inhibitors, potassium-sparing diuretics, calcium channel blockers, and beta blockers. Use as a monopreparation (Esidrex) is less common. Hydrochlorothiazide has been approved in many countries since 1958. Structure and properties Hydrochlorothiazide (C7H8ClN3O4S2, Mr = 297.7 g/mol) is a white crystalline … Hydrochlorothiazide
Products Dantrolene is commercially available in capsule form and as a solution for injection (dantamacrine, dantrolene). It has been approved in many countries since 1983. It was developed in the 1960s and 70s. This article refers primarily to peroral therapy. Structure and properties Dantrolene (C14H10N4O5, Mr = 314.3 g/mol) is present in the drug as … Dantrolene
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice
Symptoms The preliminary stages are fatigue, yawning, difficulty concentrating, headache, mood swings, lethargy, and an increased need for sleep. The actual motion sickness manifests itself acutely in symptoms such as cold sweat, pallor, pale complexion, sensations of warmth and cold, faintness, hyperventilation, rapid pulse rate, low blood pressure, salivation, nausea, nausea, vomiting, and dizziness. Triggers … Motion Sickness
