How candesartan works Like all sartans, the active ingredient candesartan interferes with the renin-angiotensin-aldosterone system (RAAS) of the human body. This regulates fluid and electrolyte balance and thus also blood pressure. To understand how sartans work, it is sufficient to look at a small section of this hormonal system. Sartans (also known as angiotensin II … Candesartan: Effects, Uses, Side Effects
Products Most sartans are commercially available as tablets or film-coated tablets. Losartan was the first agent approved in many countries in 1994 (Cosaar, USA: 1995, Cozaar). Sartans are often combined with hydrochlorothiazide fix. The name of the drug group is derived from the suffix -sartan of the active ingredients. The drugs are also called angiotensin … Sartans
Effects The RAAS is activated in the presence of low blood pressure, decreased blood volume, hyponatremia, and sympathetic activation. Main actions: mediated via angiotensin II: Vasoconstriction Blood pressure increase Release of catecholamines Hypertrophy at the heart Mediated via aldosterone: Water and sodium ions are retained Potassium ions and protons are eliminated Overview of the RAAS … Renin-Angiotensin-Aldosterone System (RAAS)
Definition Drugs today usually contain a defined active pharmaceutical ingredient. However, numerous drugs with two or more active substances also exist. These are called combination drugs or fixed combinations. For example, Aspirin C contains both acetylsalicylic acid and vitamin C. Many blood pressure medications are combination preparations, for example perindopril + indapamide or candesartan + … Combination Products
Products Candesartan is commercially available in tablet form (Atacand, Blopress, generics). It is also combined fixed with hydrochlorothiazide (Atacand plus, Blopress plus, generics). Candesartan has been approved in many countries since 1997. In 2020, a fixed combination with amlodipine was also released. Structure and Properties Candesartan (C24H20N6O3, Mr = 440.45 g/mol) is administered in the … Candesartan
Symptoms High blood pressure is often asymptomatic, meaning that no symptoms occur. Nonspecific symptoms such as headache, bleeding in the eye, nosebleeds, and dizziness are observed. In advanced disease, various organs such as the vessels, retina, heart, brain and kidney are affected. Hypertension is a known and important risk factor for atherosclerosis, dementia, cardiovascular diseases … Hypertension
Active substance Candesartan Effect of Blopress Blopress® contains the active ingredient candesartan and is a drug that is mainly used in the treatment of high blood pressure (antihypertensive). Candesartan belongs to the group of angiotensin II receptor antagonists, i.e. it blocks a receptor and thus inhibits the effects of the hormone angiotensin. Blopress® thus leads, … Blopress®
Dosage In patients with arterial hypertension, the initial dose of Blopress® should be 8 mg once daily. This is usually also the dose for permanent therapy (maintenance dose). In case of non-response, the dose can be further increased to 16 mg and a maximum of 32 mg daily. In patients with heart failure, a dose … Dosage | Blopress®
Candesartan is a commonly used drug that is used to treat high blood pressure. It has a dilating effect on the blood vessels, so that the blood pressure is lowered as a result. Side effects can therefore be dizziness or even too low blood pressure to fainting. Candesartan is often combined with other antihypertensives such … Candesartan: How the Antihypertensive Drug Works
