carbapenems

Beta Lactam Antibiotics against Bacterial Infections

Effect Beta-lactam antibiotics have bacteriostatic to bactericidal properties. They inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). PBPs include transpeptidases, which are responsible for cross-linking peptidoglycan chains during cell wall synthesis. Some beta-lactams can be degraded and thus inactivated by the bacterial enzyme beta-lactamase Indications The spectrum of beta-lactam antibiotics ranges from … Beta Lactam Antibiotics against Bacterial Infections

Vaborbactam

Products Vaborbactam was approved in the United States in 2017 as a fixed combination with the antibiotic meropenem (Vabomere, The Medicines Company). Meropenem belongs to the carbapenems and beta-lactam antibiotics group. Structure and properties Vaborbactam (C12H16BNO5S, Mr = 297.1 g/mol) is a cyclic boron compound and a boronic acid derivative. It is not a representative … Vaborbactam

Carbapeneme

Effects Carbapenems (ATC J01DH) are bactericidal against aerobic and anaerobic Gram-positive and Gram-negative pathogens. Effects are based on binding to penicillin-binding proteins (PBP) and inhibition of bacterial cell wall synthesis, resulting in bacterial dissolution and death. Imipenem, the first representative of the drug group, is degraded by the renal enzyme dehydropeptidase-I (DHP-I). It is therefore … Carbapeneme

Aztreonam: Effects, Uses & Risks

The active ingredient aztreonam is a monobactam antibiotic. The drug is used to treat infections with aerobic gram-negative bacteria. What is aztreonam? Aztreonam is the name for an antibiotic that belongs to the group of monobactams. The drug has similar pharmacodynamic and pharmacokinetic properties to penicillin. Aztreonam exerts its effect exclusively against Gram-negative bacteria. The … Aztreonam: Effects, Uses & Risks

Antibiotics: Antibacterial Drugs

Products Antibiotics (singular: antibiotic) are commercially available in the form of tablets, dispersible tablets, capsules, as infusion preparations, suspensions and syrups for children, and as granules, among others. There are also some topical preparations, such as creams, ointments, eye drops, eye ointments, ear drops, nasal ointments and sore throat tablets. The first active ingredient from … Antibiotics: Antibacterial Drugs

Meropenem

Products Meropenem is commercially available as a powder for solution for injection/infusion (Meronem, generic). It has been approved in many countries since 1995. The antibiotic is also combined with the beta-lactamase inhibitor vaborbactam. Structure and properties Meropenem (C17H25N3O5S, Mr = 383.5 g/mol) is present in drugs as meropenem trihydrate, a white to slightly yellowish crystalline … Meropenem

Tebipenem: Effects, Uses & Risks

Tebipenem is a medicinal agent that belongs to the group of carbapenems. Tebipenem is thus a so-called beta-lactam antibiotic, which goes back to penicillin. It is used to fight infectious diseases caused by bacteria. What is tebipenem? Tebipenem is an antibiotic that is administered to treat infectious diseases. The chemical molecular formula of the substance … Tebipenem: Effects, Uses & Risks

Carbapenems: Effects, Uses & Risks

Carbapenems are antibiotics that belong to the group of beta-lactams. Originally, carbapenems were called thienamycins. Due to their broad antimicrobial spectrum of activity, they are used as drugs. Some examples are ertapenem, imipenem, doripenem, meropenem and tebipenem. Carbapenems have the status of reserve antibiotics. Within Europe, more and more resistance to carbapenems is being recorded. … Carbapenems: Effects, Uses & Risks

Doripenem

Structure and properties Doripenem (C15H24N4O6S2, Mr = 420.5 g/mol) exists as doripenem monohydrate, a white to slightly yellow crystalline powder. It bears a 1-β-methyl group that protects it from degradation by dehydropeptidase I. Effects Doripenem (ATC J01DH04) is bactericidal against numerous aerobic and anaerobic Gram-positive and Gram-negative bacteria. Its effects are based on inhibition of … Doripenem

Ertapenem

Products Ertapenem is commercially available as a lyophylisate for the preparation of an infusion solution (Invanz). It has been approved in many countries since 2003. Structure and properties Ertapenem (C22H25N3O7S, Mr = 475.5 g/mol) is present in drugs as ertapenem sodium, a white, hygroscopic, weakly crystalline powder that is soluble in water. It is a … Ertapenem

Cephalosporins

Products Cephalosporins are commercially available in the form of film-coated tablets, oral suspensions, granules, and injection and infusion preparations, among others. The basis for the discovery of cephalosporins was the isolation of the mold by the physician Giuseppe Brotzu. He found the fungus in wastewater from Cagliari in Sardinia in 1945. At the University of … Cephalosporins

Imipenem: Effects, Uses & Risks

Imipenem is an antibiotic. The active substance belongs to the group of carbapenems. What is imipenem? Imipenem is a broad-spectrum antibiotic because it is effective against many different types of bacteria. Imipenem is the name given to an antibiotic drug that belongs to the carbapenem subclass. Carbapenems are considered broad-spectrum antibiotics because they are effective … Imipenem: Effects, Uses & Risks