Products Promazine is commercially available in the form of dragées (Prazine). It has been approved in many countries since 1957. Structure and properties Promazine (C17H20N2S, Mr = 284.4 g/mol) is present in drugs as promazine hydrochloride, a white crystalline powder that is very soluble in water. It is a dimethylamine derivative of phenothiazine and structurally … Promazine
Products Metamizole is commercially available as drops, tablets, suppositories, and injectables (Minalgin, Novalgin, Novaminsulfon Sintetica, generics). It has been used medicinally since the 1920s. Structure and properties Metamizole (C13H17N3O4S, Mr = 311.4 g/mol) is present in drugs as metamizole sodium. This is the sodium salt and monohydrate of the active ingredient. Metamizole sodium is a … Metamizole: Drug Effects, Side Effects, Dosage and Uses
Phenothiazines are a subgroup of thiazines. They are used primarily as neuroleptics. What are phenothiazines? Phenothiazines are derivatives of phenothiazine that are of pharmacologic relevance. In medicine, they are used as neuroleptics. There they are also known as tricyclic neuroleptics. The history of phenothiazines can be traced back to the beginning of organic chemistry. In … Phenothiazines: Effects, Uses & Risks
Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants
Products Antiemetics are commercially available in the form of tablets, as melting tablets, as solutions (drops), and injectables, among others. They are also administered as suppositories because peroral administration is not possible. In many countries, the best-known antiemetics include domperidone (Motilium, generic) and meclozine, which, along with caffeine and pyridoxine, is contained in Itinerol B6. … Antiemetics: Drugs against Nausea or Vomiting
Active ingredients Benzamides: Amisulpride (Solian, generic). Sulpiride (Dogmatil) Tiapride (Tiapridal) Benzisoxazoles: Risperidone (Risperdal, generic). Paliperidone (Invega) Benzoisothiazoles: Lurasidone (Latuda) Ziprasidone (Zeldox, Geodon) Butyrophenones: Droperidol (Droperidol Sintetica). Haloperidol (Haldol) Lumateperone (Caplyta) Pipamperone (Dipiperone) Thienobenzodiazepines: Olanzapine (Zyprexa, generic). Dibenzodiazepines: Clozapine (Leponex, generic). Dibenzoxazepines: Loxapine (Adasuve). Dibenzothiazepines: Clotiapine (Entumin) Quetiapine (Seroquel, generic). Dibenzooxepin pyrroles: Asenapine (Sycrest). Diphenylbutylpiperidines: Penfluridol … Neuroleptics Effects and Side Effects
Symptoms Photosensitivity often manifests like sunburn in extensive skin redness, pain, a burning sensation, blistering, and hyperpigmentation after healing. Other possible skin reactions include eczema, itching, urticaria, telangiectasia, tingling, and edema. The nails may also be affected less frequently and may peel off in front (photoonycholysis). The symptoms are limited to the areas of the … Photosensitivity
Hypercoagulability refers to an abnormally increased coagulability of the blood. It is associated with a tendency to form thrombi and is considered one of the main risk factors for phlebothrombosis. What is hypercoagulability? In patients with hypercoagulability, the blood clots more quickly than in healthy people. The increased clottability is caused by an increase in … Hypercoagulability: Causes, Symptoms & Treatment
Products Chlorpromazine was commercially available in various oral and parenteral dosage forms (e.g., Chlorazine, Thorazine, Largactil, Megaphene). It was first used in the 1950s as one of the first synthetic antipsychotics. Today, it is no longer a registered drug in many countries. In some countries, chlorpromazine is still on the market. Structure and properties Chlorpromazine … Chlorpromazine
Products Chlorprothixene is commercially available in the form of film-coated tablets (Truxal). It has been approved in many countries since 1960. Distribution of the so-called Truxal 5 mg tablets was discontinued in many countries in 2011 for economic reasons. Structure and properties Chlorprothixene (C18H18ClNS, Mr = 315.9 g/mol) belongs to the thioxanthenes. It is present … Chlorprothixene
Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment
Perazine is a 1st-generation, mid-potency neuroleptic. It is used to treat psychotic syndromes. In addition to schizophrenia, psychosis, anxiety disorders, delusions, and personality disorders are treated with the drug. Perazine has a sedative and antipsychotic effect by inhibiting certain neurotransmitters in the central nervous system in their action. The use and dosage of the drug … Perazine: Effects, Uses & Risks
