Aplastic anemia occurs when there is a disturbance in bone marrow function. There is a deficiency of red blood cells, white blood cells, and blood cells. What is aplastic anemia? Aplastic anemia is when there is a deficiency of red blood cells, white blood cells, and platelets due to bone marrow dysfunction. This severe reduction … Aplastic Anemia: Causes, Symptoms & Treatment
Azathioprine is one of the immunosuppressants and has multiple uses in organ transplantation, autoimmune diseases, and certain chronic inflammatory conditions. The drug’s mode of action is mediated by inhibition of nucleic acid synthesis. Because the drug acts with delays, it is always used in combination with other immunosuppressants in organ transplantation. What is azathioprine? Azathioprine … Azathioprine: Effects, Uses & Risks
Products Mesuximide is commercially available in the form of capsules (Petinutin). It has been approved in many countries since 1963. Structure and properties Mesuximide (C12H13NO2, Mr = 203.2 g/mol) belongs to the succinimides and exists as a racemate. The active metabolite -demethylmesuximide, with a long half-life of over 30 hours, is also involved in the … Mesuximide
Products Ciclosporin is commercially available as capsules, a drinkable solution, and an infusion concentrate (Sandimmune, Sandimmune Neoral, generics). It has been approved in many countries since 1995. Neoral is the microemulsion formulation that has more stable bioavailability than traditional Sandimmune. In 2016, ciclosporin eye drops were approved (see there). Structure and properties Ciclosporin (C62H111N11O12, Mr … Ciclosporin
Products Ciclosporin eye drops were approved in the EU in 2015 and in many countries in 2016 (Ikervis). They have been registered in the United States since 2009 (Restasis). Structure and properties Ciclosporin (C62H111N11O12, Mr = 1203 g/mol) exists as a white powder that is practically insoluble in water. It is extracted from the mushroom … Ciclosporin Eye Drops
Symptoms Gout is an inflammatory disease of the joints that manifests acutely in attacks of severe pain that worsens with pressure, touch, and movement. The joints are swollen with inflammation, and the skin is red and warm. Fever is observed. Gout often begins in the lower extremities and at the metatarsophalangeal joint (podagra). Urat crystals … Gout Causes and Treatment
Products Dronedarone is commercially available in the form of film-coated tablets (Multaq). It was approved in 2009, first in the United States, then in Canada, in many countries, and in November throughout the European Union. Structure and properties Dronedarone (C31H44N2O5S, Mr = 556.76 g/mol) is a benzofuran derivative and an analog of the antiarrhythmic drug … Dronedarone
Symptoms Psoriasis is a chronic inflammatory, benign, and noninfectious skin disease. It manifests as symmetrical (bilateral), sharply demarcated, bright red, dry, raised plaques covered by silvery scales. Typically affected areas are the elbows, knees, and scalp. Itching, a burning sensation and pain are other symptoms, and scratching further aggravates the condition. Psoriasis can also affect … Psoriasis Causes and Treatment
Products Fenofibrate is commercially available in the form of capsules (lipanthyl). It has been approved in many countries since 1977. In 2014, a fixed combination with simvastatin was registered (Cholib); see Fenofibrate Simvastatin. Structure and properties Fenofibrate (C20H21ClO4, Mr = 360.8 g/mol) exists as a white crystalline powder that is practically insoluble in water. It … Fenofibrate
The active substance trimethoprim is an antibiotic that belongs to the category of diaminopyrimidines. The drug is used in the treatment of infections caused by bacteria. The drug trimethoprim is especially frequently used for the treatment of cystitis in female patients. As a rule, the drug is taken in the morning and evening after meals. … Trimethoprim: Effects, Uses & Risks
Products Allopurinol is in the form of tablets trade (Zyloric, generic). It is approved in many countries since the year 1966. Allopurinol is also combined with the URAT1 inhibitor lesinurad. Structure and properties Allopurinol (C5H4N4O, Mr = 136.1 g/mol) exists as a white powder that is very sparingly soluble in water. It is a derivative … Allopurinol (Zyloprim)
Products Rabeprazole is commercially available in the form of film-coated tablets (Pariet, generic). It has been approved in many countries since 1999. Generic versions have been available since 2012. Structure and properties Rabeprazole (C18H21N3O3S, Mr = 359.4 g/mol) is a benzimidazole and pyridine derivative and a racemate. It is present in drugs as rabeprazole sodium, … Rabeprazole
