Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval
Diseases such as gastritis, peptic ulcer, or the use of medications that are harmful to the stomach may require the use of a stomach-protecting, acid-inhibiting agent. Modern medicine has a number of appropriate drugs available that work effectively and gently. One of the most commonly prescribed agents is omeprazole. What is omeprazole? The active ingredient … Omeprazole: Effects, Uses & Risks
The drug prochlorperazine is used in human medicine primarily as a medication for nausea, vomiting, and migraine. Occasionally, the dopamine antagonist is also prescribed to treat psychiatric or mental illness. Accordingly, prochlorperazine is both an antiemetic and a neuroleptic. What is prochlorperazine? The active medical ingredient prochlorperazine belongs to the group of antiemetics. This term … Prochlorperazine: Effects, Uses & Risks
Products Dronedarone is commercially available in the form of film-coated tablets (Multaq). It was approved in 2009, first in the United States, then in Canada, in many countries, and in November throughout the European Union. Structure and properties Dronedarone (C31H44N2O5S, Mr = 556.76 g/mol) is a benzofuran derivative and an analog of the antiarrhythmic drug … Dronedarone
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice
Products Erythromycin is commercially available for peroral administration in tablet and granular form (Erythrocin / Erythrocin ES). This article refers to the drugs intended for ingestion. Erythromycin was first approved in the 1950s. Structure and properties Erythromycin is a natural substance produced by the bacterium (formerly: ). In oral medications, it is present as erythromycin … Erythromycin
Products Aprepitant is commercially available in the form of capsules (Emend). It has been approved in many countries since 2003. Structure and properties Aprepitant (C23H21F7N4O3, Mr = 534.4 g/mol) is a morpholine and triazol-3-one derivative. It exists as a white crystalline powder that is practically insoluble in water. For intravenous use, the more water-soluble prodrug … Aprepitant
Products Prucalopride is commercially available in the form of film-coated tablets (Resolor). It was approved in many countries and in the EU in 2010. Structure and properties Prucalopride (C18H26ClN3O3, Mr = 367.87 g/mol) is a dihydrobenzofurancarboxamide. It has structural similarities to the prokinetic cisapride (prepulside, out of commerce). Effects Prucalopride (ATC A03AE04) has enterokinetic properties, … Prucalopride
The active ingredient cisapride is one of the prokinetics that increase motility of the gastrointestinal tract. The active ingredient causes severe cardiac side effects and has therefore been withdrawn from the market in many countries. Its use is not recommended; safer drugs from the prokinetic group are available. What is cisapride? Cisapride belongs to the … Cisapride: Effects, Uses & Risks
Products Cisapride (Prepulsid, various dosage forms) was withdrawn from the market in many countries at the end of 2004 and is no longer commercially available. Structure and properties Cisapride (C23H29ClFN3O4), Mr = 465.9 g/mol) Effects Cisapride (ATC A03FA02) has prokinetic properties and improves motility of the digestive tract. The effects are due to agonism at … Cisapride
Products Mibefradil (Posicor tablets) was launched in many countries in 1996 and withdrawn from the market in 1998 because of potential interactions. It is no longer commercially available. Structure and properties Mibefradil (C29H38FN3O3, Mr = 495.6 g/mol) is a benzimidazole and a tetralol derivative. It is present in drugs as mibefradildihydrochloride. Effects Mibefradil (ATC C08CX01) … Mibefradil
Products Tolterodine is commercially available in the form of sustained-release capsules (Detrusitol SR). It has been approved in many countries since 2000. Its successor product, fesoterodine (Toviaz), was launched in 2008 and desfesoterodine (Tovedeso) in 2019. A non-retarded preparation is also commercially available in the United States (Detrol). Structure and properties Tolterodine (C22H31NO, Mr = … Tolterodine
