Products Trimebutin is commercially available as granules and in the form of film-coated tablets (debridate). It has been approved in many countries since 1990. Structure and properties Trimebutine (C22H29NO5, Mr = 387.5 g/mol is present in drugs as trimebutin hydrogenomaleate. Effects Trimebutin (ATC A03AA05) is prokinetic and stimulates intestinal motility. Effects are due to binding … Trimebutin
Products Prucalopride is commercially available in the form of film-coated tablets (Resolor). It was approved in many countries and in the EU in 2010. Structure and properties Prucalopride (C18H26ClN3O3, Mr = 367.87 g/mol) is a dihydrobenzofurancarboxamide. It has structural similarities to the prokinetic cisapride (prepulside, out of commerce). Effects Prucalopride (ATC A03AE04) has enterokinetic properties, … Prucalopride
Products Cisapride (Prepulsid, various dosage forms) was withdrawn from the market in many countries at the end of 2004 and is no longer commercially available. Structure and properties Cisapride (C23H29ClFN3O4), Mr = 465.9 g/mol) Effects Cisapride (ATC A03FA02) has prokinetic properties and improves motility of the digestive tract. The effects are due to agonism at … Cisapride
Products Domperidone is commercially available as film-coated tablets, lingual tablets, and as a suspension (Motilium, generics). It was synthesized in 1974 and has been approved in many countries since 1979. Structure and properties Domperidone (C22H24ClN5O2, Mr = 425.9 g/mol) exists as a white powder that is practically insoluble in water. It is a benzimidazole derivative … Domperidone
Products Alizapride is commercially available in tablet form and as a solution for injection (Vergentan). The drug is not registered in many countries. Structure and properties Alizapride (C16H21N5O2, Mr = 315.4 g/mol) is structurally related to metoclopramide. Effects Alizapride (ATC A03FA05) has prokinetic and antiemetic properties. The effects are due to antagonism at dopamine receptors … Alizapride
Products Metoclopramide is commercially available in tablet, solution, and solution for injection (Primpéran, Paspertin). It has been approved in many countries since 1967. The drops and suppositories for children were withdrawn from the market in November 2011 because of the risk for extrapyramidal side effects. Structure and properties Metoclopramide (C14H22ClN3O2, Mr = 299.8 g/mol) is … Metoclopramide
Products No drugs containing clebopride are on the market in many countries. Structure and properties Cleboprid (C20H24ClN3O2, Mr = 373.9 g/mol) is present in drugs as clebopride malate, a white crystalline powder that is sparingly soluble in water. Clebopride is a substituted benzamide. Effects Clebopride (ATC A03FA06) has prokinetic and antiemetic properties. Indications For the … Cleboprid
