How clonidine works Clonidine lowers the release of the messenger substances of the sympathetic nervous system, adrenaline and noradrenaline, by activating alpha-2 receptors (docking sites). The end result is a reduction in blood pressure and heart rate, minor sedation, and pain relief. Clonidine is a so-called antisympathotonic (inhibits the action of the sympathetic nervous system). … Clonidine: Effects, application, side effects
Symptoms Attention deficit hyperactivity disorder (ADHD, ADHD) is a developmental disorder of the central nervous system. Leading symptoms include: Inattention, decreased ability to concentrate. Hyperactivity, motor restlessness, restlessness. Impulsive (thoughtless) behavior Emotional problems Although ADHD begins in childhood, it also affects adolescents and adults and is more common in boys than girls. It presents itself, … Attention Deficit Hyperactivity Disorder
Products Sympatholytics are commercially available in the form of tablets, capsules, as injectables, and eye drops, among others. Effects Sympatholytics have sympatholytic properties, meaning that they abolish the effects of the sympathetic nervous system, a portion of the autonomic nervous system. Their effects are usually due to direct antagonism at adrenoceptors. Indirect sympatholytics reduce the … Sympatholytics
Products Moxonidine is commercially available in tablet form (Physiotens). It has been approved in many countries since 1993. Structure and properties Moxonidine (C9H12ClN5O, Mr = 241.7 g/mol) exists as a white powder that is very sparingly soluble in water. It is an imidazoline derivative structurally related to clonidine. Effects Moxonidine (ATC C02AC05) has central antihypertensive … Moxonidine
Products Lofexidine was approved in the United States in 2018 in film-coated tablet form (Lucemyra). In the United Kingdom, the agent was approved for the treatment of opioid withdrawal back in the early 1990s (UK: BritLofex). Structure and properties Lofexidine (C11H12Cl2N2O, Mr = 259.1 g/mol) is present in the drug as lofexidine hydrochloride, a white … Lofexidine
Products Transdermal patches are approved as medicinal products. They offer themselves as an alternative to other modes of application such as peroral and parenteral administration. The first products were launched in the 1970s. Structure and properties Transdermal patches are flexible pharmaceutical preparations of varying sizes and thinness that contain one or more active ingredients. They … Transdermal Patches
Products Clonidine is commercially available in many countries as tablets and as a solution for injection and has been approved since 1970 (Catapresan). In some countries, clonidine is approved for the treatment of ADHD (eg, Kapvay sustained-release tablets). This article refers to its use in ADHD. Structure and Properties Clonidine (C9H9Cl2N3, Mr = 230.1 g/mol) … Clonidine: Drug Effects, Side Effects, Dosage and Uses
Active ingredients ACE inhibitors Sartans Renin inhibitors Calcium channel blockers Beta blockers Diuretics Alpha blockers Centrally acting antihypertensives: Clonidine Methyldopa Moxonidine Reserpine Organic nitrates Herbal antihypertensives: Garlic Hawthorn
Products Methylphenidate is commercially available in many countries in the form of tablets, film-coated tablets, sustained-release tablets, and sustained-release capsules (e.g., Ritalin, Concerta, Medikinet, Equasym, generics). It has been approved since 1954. The drug is subject to strict control as a narcotic and is available only by prescription. The isomer dexmethylphenidate (Focalin XR) is also … Methylphenidate: Drug Effects, Side Effects, Dosage and Uses
Products Xylazine is commercially available as a solution for injection. It is approved exclusively as a veterinary drug in many countries and has been since 1970. Structure and properties Xylazine (C12H16N2S, Mr = 220.3 g/mol) is a thiazine derivative. It exists as a white crystalline powder that is readily soluble in water. In veterinary medicine … Xylazine
Products Tizanidine is commercially available in tablet and sustained-release capsule form (Sirdalud, Sirdalud MR, generics). It has been approved in many countries since 1983. Structure and properties Tizanidine (C9H8ClN5S, Mr = 253.7 g/mol) is present in drugs as tizanidine hydrochloride, a white crystalline powder that is somewhat soluble in water. It is an imidazoline and … Tizanidin
Products Apraclonidine is commercially available in the form of eye drops (iopidine). It has been approved in many countries since 1995. Structure and properties Apraclonidine (C9H10Cl2N4, Mr = 245.1 g/mol) is an amino derivative of clonidine. It is present in the drug as apraclonidine hydrochloride, a white powder that is highly soluble in water. Effects … Apraclonidine
