Products Stavudine is commercially available in capsule form (Zerit). It has been approved in many countries since 1996. Structure and properties Stavudine (C10H12N2O4, Mr = 224.2 g/mol) is a thymidine analog with a missing 3′-hydroxy group. It is a prodrug that is biotransformed intracellularly to the active metabolite stavudine triphosphate. Stavudine exists as a white … Stavudine
Didanosine is a drug used in the treatment against infection with the HIV virus. The active ingredient belongs to the virus-inhibiting agents and thereby serves to strengthen the immune system of HIV patients. What is didanosine? Didanosine is a drug that is used in the treatment against infection with the HIV virus. Didanosine generally strengthens … Didanosine: Effects, Uses & Risks
Effects Reverse transcriptase inhibitors (ATC J05AF) have antiviral properties against HIV. The effects are due to inhibition of the viral enzyme reverse transcriptase, which transcribes viral RNA into DNA and is important for viral replication. Structure and properties Within the drug group, two distinct classes are distinguished. The so-called nucleoside reverse transcriptase inhibitors, abbreviated NRTIs, … Reverse Transcriptase Inhibitors (HIV)
Products Lymecycline is commercially available in the form of capsules (Tetralysal). It was approved in many countries in 2005. Structure and properties Lymecycline (C29H38N4O10, Mr = 602.6 g/mol) is a water-soluble prodrug of the antibiotic tetracycline with the amino acid lysine. Lymecycline is better absorbed than tetracycline. Effects Lymecycline (ATC J01AA04) has bacteriostatic properties against … Lymecycline
The active ingredient saquinavir is a protease inhibitor. The drug is primarily used for the therapy of HIV infections. In this context, the substance saquinavir is mainly used in combination preparations. The drug was approved in 1995. Since a large number of patients quickly developed resistance to the drug, saquinavir was taken off the pharmaceutical … Saquinavir: Effects, Uses & Risks
Zalcitabine is a so-called antiviral drug for oral administration. It is classified as a member of the nucleoside reverse transcriptase inhibitor (NRTI) group of drugs and is used in the antiviral therapy of HIV infection. What is zalcitabine? Zalcitabine belongs to the NRTI group of drugs, which are antiretroviral agents. It was first produced by … Zalcitabine: Effects, Uses & Risks
Products Didanosine was commercially available in the form of capsules (Videx EC). It was first approved in 1991 as the second HIV drug after AZT (EC = enteric coated, capsules filled with enteric granules). Structure and properties Didanosine (C10H12N4O3, Mr = 236.2 g/mol) corresponds to 2′,3′-dideoxyinosine, a synthetic nucleoside analog of deoxyadenosine. The 3′-hydroxy group … Didanosine
Atazanavir is an active medical substance. It is used to treat HIV infection. What is atazanavir? Atazanavir is a medical active ingredient. It is used for the therapy of HIV infections. The drug atazanavir is commercially available in Germany under the name Reyataz. It is taken orally and is used to treat HIV infections. The … Atazanavir: Effects, Uses & Risks
Products Ribavirin is commercially available in the form of film-coated tablets (Copegus). It has been approved in many countries since 1990. Structure and properties Ribavirin (C8H12N4O5, Mr = 244.2 g/mol) is a purine nucleoside analog. It exists as a white crystalline powder that is readily soluble in water. In cells, the drug is biotransformed to … Ribavirin
Products Norfloxacin is commercially available in the form of film-coated tablets. It was approved in many countries in 1983. The original product, Noroxin, is no longer available, but generics are available. Structure and properties Norfloxacin (C16H18FN3O3, 319.33 g/mol) is a fluoroquinolone. It exists as a white to pale yellow, hygroscopic, photosensitive crystalline powder that is … Norfloxacin
A nucleoside analog is a substance that resembles a natural nucleoside. In particular, these are drugs used for antiviral treatment (known as nucleoside reverse transcriptase inhibitors, NRTIs). Nucleoside analogues therefore play a significant role in the treatment of infectious diseases such as HIV, hepatitis B (HBV), and hepatitis C (HBC). What are nucleoside analogues? The … Nucleoside Analogues: Efficacy, Uses & Risks
Hardly anyone doubts that hepatitis C (170 million infected worldwide) and HIV (40 million infected) are global problems. Both viral infections have in common that no complete cure is possible, but only a mitigation or suppression of the course of the disease. Here, among other things, the virus-inhibiting agent ribavirin plays an important role. What … Ribavirin: Effects, Uses & Risks
