Products Elotuzumab was approved in the United States in 2015 and in the EU and Switzerland in 2016 as a powder for the preparation of an infusion solution (Empliciti). Structure and properties Elotuzumab is a humanized IgG1 monoclonal antibody with a molecular weight of 148.1 kDa. It is produced by biotechnological methods. Effects Elotuzumab (ATC … Elotuzumab
Products Alemtuzumab is commercially available as a concentrate for the preparation of an infusion solution (Lemtrada). It was approved in 2014. Alemtuzumab was originally approved for leukemia treatment and marketed as MabCampath (approved in 2001). Structure and properties Alemtuzumab is a humanized IgG1 kappa monoclonal antibody to CD52 produced by biotechnological methods. It has a … Alemtuzumab
Products Gefitinib is commercially available in the form of film-coated tablets (Iressa). It was approved in many countries in 2011. Structure Gefitinib (C22H24ClFN4O3, Mr = 446.9 g/mol) is a morpholine and aniline quinazoline derivative. It exists as a white powder that is sparingly soluble in water, especially at high pH. Effects Gefitinib (ATC L01XE02) is … Gefitinib
Products and approval Fingolimod is commercially available in capsule form (Gilenya) and has been approved in many countries since 2011. First generic products were registered in 2020 and entered the market in 2021. Fingolimod was the first specific multiple sclerosis drug to be administered orally, rather than being injected subcutaneously or as an infusion. In … Fingolimod
Products Firocoxib is commercially available as chewable tablets for dogs and as a paste for administration in horses. It has been approved in many countries since 2004. Structure and properties Firocoxib (C17H20O5S, Mr = 336.4 g/mol) is a furanone derivative. Like other COX-2 inhibitors, it has a V-shaped structure that allows binding to the Active … Firocoxib
Products Omeprazole is commercially available in tablet, capsule, and injection/infusion forms and has been approved in many countries since 1988. In addition to the original Antramups, generics and the -enantiomer esomeprazole (Nexium) are also commercially available. At the end of March 2010, after pantoprazole, omeprazole was also approved for self-medication in many countries. In the … Omeprazole: Drug Effects, Side Effects, Dosage and Uses
Background It is estimated that more than 180 million people worldwide are chronically infected with the hepatitis C virus. Potential severe complications of hepatitis include cirrhosis, liver carcinoma, and liver failure. Of the various genotypes of the virus, genotype 1 in particular responds poorly to current treatment (50%). Standard drugs used include subcutaneous peginterferon alfa … Boceprevir
Products Ketoprofen is commercially available as a gel (Fastum). It has been approved in many countries since 1992 and in the EU since 1978. The -enantiomer dexketoprofen is available as tablets and as a solution for injection (Ketesse). This article refers to external use. After the safety of topical ketoprofen was questioned in France in … Ketoprofen
Products Febuxostat is commercially available in the form of film-coated tablets (Adenuric). It was approved in many countries in 2016. It was registered in the EU in 2008 and in the US in 2009 (US: Uloric). Structure and properties Febuxostat (C16H16N2O3S, Mr = 316.4 g/mol), unlike allopurinol, does not have a purine structure. It is … Febuxostat
Products Cabazitaxel is released as a concentrate for the preparation of an infusion solution. It has been approved in many countries since 2011 (Jevtana). Structure and properties Cabazitaxel (C45H57NO14, Mr = 835.9 g/mol) is a taxane semisynthetically derived from a constituent of yew needles. It is structurally closely related to docetaxel, which is itself a … Cabazitaxel
Products Orlistat is available in many countries in the form of capsules and has been approved since 1998 (Xenical, 120 mg, Roche Pharmaceuticals). In 2009, it was also approved for self-medication after specialist consultation with healthcare professionals without a doctor’s prescription at half the dosage (Alli, 60 mg, GlaxoSmithKline). The generic Xenical drug Orlistat Sandoz … Orlistat: Drug Effects, Side Effects, Dosage and Uses
Products Retapamulin is commercially available as an ointment (Altargo). It was approved in the EU in 2007 and in many countries in 2009. Structure and properties Retapamulin is a semisynthetic derivative of pleuromutilin derived from the pillz (cat’s ear). Effects Retapamulin (ATC D06AX13) is bacteriostatic against and by inhibiting bacterial protein synthesis via ribosomal binding. … Retapamulin
